LINC00376

Summary

LINC00376 (long intergenic non-protein coding RNA 376, HGNC:42701) is a long non-coding RNA gene on chromosome 13q21.31.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:42701
Approved symbol	LINC00376
Name	long intergenic non-protein coding RNA 376
Location	13q21.31
Locus type	RNA, long non-coding
Status	Approved
Aliases	RP11-527N12.1
Ensembl gene	ENSG00000227564
Ensembl biotype	lncRNA
Entrez	104355293
RNAcentral	URS000077D06F — lncRNA, 693 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 8 — 8 lncRNA

ENST00000439454, ENST00000836363, ENST00000836364, ENST00000836365, ENST00000836366, ENST00000836367, ENST00000836368, ENST00000836369

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000439454 — 7 exons

Exon	Start	End
ENSE00001666709	63183096	63183328
ENSE00001710796	63194490	63194531
ENSE00001780948	63226979	63227068
ENSE00003741228	63327248	63327355
ENSE00003744707	63232013	63232131
ENSE00003746945	63328054	63328129
ENSE00003747200	63264211	63264275

Expression profiles

Bgee: expression breadth broad, 36 present calls, max score 78.14.

Top tissues by expression

36 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	78.14	silver quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	69.40	gold quality
right testis	UBERON:0004534	57.27	gold quality
monocyte	CL:0000576	56.90	gold quality
testis	UBERON:0000473	56.87	gold quality
left testis	UBERON:0004533	56.80	gold quality
endometrium	UBERON:0001295	54.85	silver quality
multicellular organism	UBERON:0000468	53.72	gold quality
blood	UBERON:0000178	52.03	gold quality
pancreas	UBERON:0001264	49.18	silver quality
gastrocnemius	UBERON:0001388	48.59	gold quality
spleen	UBERON:0002106	48.03	gold quality
tibial artery	UBERON:0007610	46.51	gold quality
subcutaneous adipose tissue	UBERON:0002190	46.46	gold quality
esophagus mucosa	UBERON:0002469	45.93	silver quality
small intestine Peyer’s patch	UBERON:0003454	45.50	gold quality
tibial nerve	UBERON:0001323	45.43	gold quality
heart left ventricle	UBERON:0002084	44.55	silver quality
vagina	UBERON:0000996	44.21	gold quality
skin of abdomen	UBERON:0001416	43.51	silver quality
right atrium auricular region	UBERON:0006631	43.10	silver quality
skin of leg	UBERON:0001511	43.09	gold quality
myometrium	UBERON:0001296	41.80	gold quality
lower esophagus muscularis layer	UBERON:0035833	40.45	silver quality
body of pancreas	UBERON:0001150	40.44	silver quality
muscle layer of sigmoid colon	UBERON:0035805	39.45	silver quality
left lobe of thyroid gland	UBERON:0001120	39.23	silver quality
body of uterus	UBERON:0009853	38.28	silver quality
brain	UBERON:0000955	38.03	silver quality
left ovary	UBERON:0002119	37.96	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	2.93

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.