LINC00378

Summary

LINC00378 (long intergenic non-protein coding RNA 378, HGNC:42704) is a long non-coding RNA gene on chromosome 13q21.2.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:42704
Approved symbol	LINC00378
Name	long intergenic non-protein coding RNA 378
Location	13q21.2
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000225249
Ensembl biotype	lncRNA
Entrez	101926930
RNAcentral	URS000075AD84 — lncRNA, 519 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 21 — 21 lncRNA

ENST00000413402, ENST00000455894, ENST00000654911, ENST00000656826, ENST00000656845, ENST00000658247, ENST00000662792, ENST00000663355, ENST00000666620, ENST00000669309, ENST00000767762, ENST00000767763, ENST00000767764, ENST00000767766, ENST00000767768, ENST00000767769, ENST00000767770, ENST00000767771, ENST00000767772, ENST00000767773, ENST00000789290

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000413402 — 3 exons

Exon	Start	End
ENSE00001646491	60685199	60685352
ENSE00001761428	60690773	60690864
ENSE00001780204	60693912	60694068

Expression profiles

Bgee: expression breadth broad, 78 present calls, max score 83.77.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.0127 / max 12.6304, expressed in 3 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
135286	0.0089	3
135285	0.0038	3

Top tissues by expression

78 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	83.77	gold quality
left testis	UBERON:0004533	73.27	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	73.13	gold quality
testis	UBERON:0000473	73.13	gold quality
right testis	UBERON:0004534	72.25	gold quality
colonic epithelium	UBERON:0000397	66.63	silver quality
right ovary	UBERON:0002118	60.80	gold quality
monocyte	CL:0000576	59.07	gold quality
skeletal muscle tissue	UBERON:0001134	56.65	silver quality
lymph node	UBERON:0000029	53.79	gold quality
kidney	UBERON:0002113	52.67	silver quality
multicellular organism	UBERON:0000468	52.39	gold quality
blood	UBERON:0000178	52.24	gold quality
spleen	UBERON:0002106	52.22	gold quality
prefrontal cortex	UBERON:0000451	50.82	gold quality
calcaneal tendon	UBERON:0003701	50.69	silver quality
muscle of leg	UBERON:0001383	50.26	gold quality
adult mammalian kidney	UBERON:0000082	50.16	silver quality
gastrocnemius	UBERON:0001388	50.11	gold quality
islet of Langerhans	UBERON:0000006	48.50	gold quality
cortex of kidney	UBERON:0001225	48.26	silver quality
left adrenal gland	UBERON:0001234	48.15	gold quality
body of stomach	UBERON:0001161	47.91	gold quality
tonsil	UBERON:0002372	47.39	gold quality
stomach	UBERON:0000945	47.21	gold quality
minor salivary gland	UBERON:0001830	46.95	gold quality
cerebellar cortex	UBERON:0002129	46.83	gold quality
right hemisphere of cerebellum	UBERON:0014890	46.68	gold quality
primary visual cortex	UBERON:0002436	46.57	silver quality
heart	UBERON:0000948	46.52	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.80

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.