LINC00423

Summary

LINC00423 (long intergenic non-protein coding RNA 423, HGNC:42758) is a long non-coding RNA gene on chromosome 13q13.1.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:42758
Approved symbol	LINC00423
Name	long intergenic non-protein coding RNA 423
Location	13q13.1
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000226968
Ensembl biotype	lncRNA
Entrez	100874167
RNAcentral	URS000075E824 — lncRNA, 1370 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 3 — 3 lncRNA

ENST00000421002, ENST00000809040, ENST00000809041

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000421002 — 4 exons

Exon	Start	End
ENSE00001624827	32911023	32911650
ENSE00001689237	32906894	32907017
ENSE00001708268	32877431	32877497
ENSE00001751067	32910637	32910720

Expression profiles

Bgee: expression breadth broad, 36 present calls, max score 58.69.

Top tissues by expression

36 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
lymph node	UBERON:0000029	58.69	gold quality
blood	UBERON:0000178	54.87	silver quality
lung	UBERON:0002048	52.81	gold quality
islet of Langerhans	UBERON:0000006	50.38	gold quality
thyroid gland	UBERON:0002046	50.27	silver quality
monocyte	CL:0000576	49.98	silver quality
gastrocnemius	UBERON:0001388	49.24	gold quality
heart	UBERON:0000948	48.64	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	48.07	gold quality
vermiform appendix	UBERON:0001154	46.35	gold quality
subcutaneous adipose tissue	UBERON:0002190	45.42	gold quality
adult mammalian kidney	UBERON:0000082	44.89	silver quality
tonsil	UBERON:0002372	44.24	silver quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	44.02	silver quality
muscle layer of sigmoid colon	UBERON:0035805	43.05	gold quality
Ammon’s horn	UBERON:0001954	42.17	silver quality
lower esophagus muscularis layer	UBERON:0035833	40.60	silver quality
tibial artery	UBERON:0007610	40.26	silver quality
caudate nucleus	UBERON:0001873	40.11	silver quality
esophagus mucosa	UBERON:0002469	39.95	silver quality
esophagogastric junction muscularis propria	UBERON:0035841	39.51	silver quality
spleen	UBERON:0002106	39.36	silver quality
zone of skin	UBERON:0000014	39.04	silver quality
putamen	UBERON:0001874	39.04	silver quality
cerebral cortex	UBERON:0000956	38.72	silver quality
Brodmann (1909) area 9	UBERON:0013540	38.33	silver quality
frontal cortex	UBERON:0001870	38.10	silver quality
right atrium auricular region	UBERON:0006631	38.00	silver quality
nucleus accumbens	UBERON:0001882	36.87	silver quality
body of stomach	UBERON:0001161	36.50	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.64

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• linc00423 acts as the tumor suppressor in retroperitoneal liposarcoma cells through regulating the protein level of NFATC3 at a post-transcriptional level and negatively regulated the MAPK signaling pathway at a transcriptional level. (PMID:31160581)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.