LINC00426

Summary

LINC00426 (long intergenic non-protein coding RNA 426, HGNC:42761) is a long non-coding RNA gene on chromosome 13q12.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:42761
Approved symbol	LINC00426
Name	long intergenic non-protein coding RNA 426
Location	13q12.3
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000238121
Ensembl biotype	lncRNA
Entrez	100188949
RNAcentral	URS000075D069 — lncRNA, 1608 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 18 — 18 lncRNA

ENST00000416261, ENST00000417079, ENST00000420210, ENST00000420219, ENST00000429808, ENST00000444319, ENST00000447147, ENST00000450327, ENST00000452659, ENST00000654979, ENST00000655621, ENST00000657545, ENST00000693355, ENST00000718390, ENST00000718391, ENST00000718392, ENST00000718393, ENST00000850858

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000416261 — 3 exons

Exon	Start	End
ENSE00001593690	30373387	30374093
ENSE00001720506	30376827	30376964
ENSE00004282532	30375467	30375776

Expression profiles

Bgee: expression breadth ubiquitous, 133 present calls, max score 89.55.

FANTOM5 (CAGE): breadth broad, TPM avg 2.0048 / max 172.4727, expressed in 199 samples.

FANTOM5 promoters (6 alternative TSS)

Promoter ID	TPM avg	Samples expressed
136628	1.5349	152
136627	0.2087	86
136631	0.1075	49
136629	0.0846	50
136630	0.0575	32
136632	0.0116	5

Top tissues by expression

133 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
lymph node	UBERON:0000029	89.55	gold quality
granulocyte	CL:0000094	83.75	gold quality
vermiform appendix	UBERON:0001154	83.11	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	82.71	silver quality
spleen	UBERON:0002106	82.52	gold quality
blood	UBERON:0000178	82.34	gold quality
tonsil	UBERON:0002372	80.27	gold quality
small intestine Peyer’s patch	UBERON:0003454	78.08	gold quality
small intestine	UBERON:0002108	77.18	gold quality
bone marrow cell	CL:0002092	76.45	gold quality
bone marrow	UBERON:0002371	76.25	gold quality
rectum	UBERON:0001052	74.38	gold quality
colonic epithelium	UBERON:0000397	73.22	gold quality
mucosa of transverse colon	UBERON:0004991	73.18	gold quality
gall bladder	UBERON:0002110	71.58	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	71.34	gold quality
transverse colon	UBERON:0001157	67.99	gold quality
leukocyte	CL:0000738	67.89	gold quality
right lobe of liver	UBERON:0001114	67.53	gold quality
intestine	UBERON:0000160	67.40	gold quality
liver	UBERON:0002107	67.37	gold quality
duodenum	UBERON:0002114	67.21	gold quality
monocyte	CL:0000576	66.60	gold quality
urinary bladder	UBERON:0001255	66.54	gold quality
cortical plate	UBERON:0005343	66.48	gold quality
smooth muscle tissue	UBERON:0001135	65.72	gold quality
right lung	UBERON:0002167	65.07	gold quality
superior frontal gyrus	UBERON:0002661	64.46	gold quality
body of stomach	UBERON:0001161	64.04	gold quality
lung	UBERON:0002048	64.03	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	4.71

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 3)

• Bioinformatics analysis of LINC00426 expression in lung cancer and its correlation with patients’ prognosis. (PMID:31691516)
• An Integrating Immune-Related Signature to Improve Prognosis of Hepatocellular Carcinoma. (PMID:33204302)
• Linc00426 accelerates lung adenocarcinoma progression by regulating miR-455-5p as a molecular sponge. (PMID:33311443)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.