LINC00446

Summary

LINC00446 (long intergenic non-protein coding RNA 446, HGNC:42783) is a long non-coding RNA gene on chromosome 13q22.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:42783
Approved symbol	LINC00446
Name	long intergenic non-protein coding RNA 446
Location	13q22.3
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000229249
Ensembl biotype	lncRNA
Entrez	100874175
RNAcentral	URS000075C5EA — lncRNA, 623 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 8 — 8 lncRNA

ENST00000414743, ENST00000438327, ENST00000652987, ENST00000658245, ENST00000659347, ENST00000661792, ENST00000736684, ENST00000736685

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000414743 — 5 exons

Exon	Start	End
ENSE00001657951	78029922	78030080
ENSE00001678722	78037196	78037219
ENSE00001782399	78031863	78031984
ENSE00003694748	78013675	78013763
ENSE00003701480	78012883	78012947

Expression profiles

Bgee: expression breadth broad, 59 present calls, max score 72.34.

Top tissues by expression

59 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
liver	UBERON:0002107	72.34	gold quality
sural nerve	UBERON:0015488	67.46	silver quality
endometrium	UBERON:0001295	61.34	silver quality
right testis	UBERON:0004534	60.27	gold quality
testis	UBERON:0000473	60.12	gold quality
left testis	UBERON:0004533	59.87	gold quality
islet of Langerhans	UBERON:0000006	57.26	gold quality
kidney	UBERON:0002113	56.11	gold quality
cortex of kidney	UBERON:0001225	53.81	gold quality
multicellular organism	UBERON:0000468	51.61	gold quality
blood	UBERON:0000178	51.21	gold quality
gastrocnemius	UBERON:0001388	50.14	gold quality
body of pancreas	UBERON:0001150	49.98	gold quality
prefrontal cortex	UBERON:0000451	49.84	gold quality
lower esophagus muscularis layer	UBERON:0035833	49.80	gold quality
monocyte	CL:0000576	49.60	silver quality
calcaneal tendon	UBERON:0003701	46.38	silver quality
putamen	UBERON:0001874	45.64	gold quality
esophagus mucosa	UBERON:0002469	44.70	silver quality
Ammon’s horn	UBERON:0001954	43.86	gold quality
corpus callosum	UBERON:0002336	43.82	silver quality
ascending aorta	UBERON:0001496	43.41	silver quality
omental fat pad	UBERON:0010414	43.41	gold quality
tibial artery	UBERON:0007610	43.12	silver quality
subcutaneous adipose tissue	UBERON:0002190	42.66	silver quality
amygdala	UBERON:0001876	42.52	gold quality
body of stomach	UBERON:0001161	42.48	silver quality
brain	UBERON:0000955	41.66	gold quality
skin of leg	UBERON:0001511	41.38	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	41.22	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	2.93

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.