LINC00448

Summary

LINC00448 (long intergenic non-protein coding RNA 448, HGNC:42785) is a long non-coding RNA gene on chromosome 13q21.31.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:42785
Approved symbol	LINC00448
Name	long intergenic non-protein coding RNA 448
Location	13q21.31
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000228669
Ensembl biotype	lncRNA
Entrez	100874176
RNAcentral	URS0000759D8D — lncRNA, 798 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 18 — 18 lncRNA

ENST00000438352, ENST00000448411, ENST00000656857, ENST00000657217, ENST00000658776, ENST00000667975, ENST00000671427, ENST00000757076, ENST00000757077, ENST00000757078, ENST00000757079, ENST00000757080, ENST00000757081, ENST00000757082, ENST00000757083, ENST00000757084, ENST00000757085, ENST00000757086

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000438352 — 5 exons

Exon	Start	End
ENSE00001785179	62732294	62732364
ENSE00003879544	62732663	62732732
ENSE00003883893	62731720	62732195
ENSE00003885216	62794496	62794571
ENSE00004107759	62796560	62796726

Expression profiles

Bgee: expression breadth broad, 96 present calls, max score 88.35.

Top tissues by expression

96 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	88.35	gold quality
left testis	UBERON:0004533	74.47	gold quality
testis	UBERON:0000473	74.17	gold quality
right testis	UBERON:0004534	71.69	gold quality
sural nerve	UBERON:0015488	60.80	gold quality
lymph node	UBERON:0000029	52.77	gold quality
prefrontal cortex	UBERON:0000451	51.80	gold quality
monocyte	CL:0000576	51.79	gold quality
left ovary	UBERON:0002119	51.19	gold quality
ovary	UBERON:0000992	50.39	gold quality
cortex of kidney	UBERON:0001225	49.11	gold quality
blood	UBERON:0000178	49.04	gold quality
tibial artery	UBERON:0007610	48.76	gold quality
popliteal artery	UBERON:0002250	48.74	gold quality
body of uterus	UBERON:0009853	48.33	gold quality
mucosa of transverse colon	UBERON:0004991	48.28	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	48.11	gold quality
multicellular organism	UBERON:0000468	47.99	gold quality
right lobe of liver	UBERON:0001114	47.54	silver quality
right ovary	UBERON:0002118	47.43	gold quality
endocervix	UBERON:0000458	47.00	gold quality
myometrium	UBERON:0001296	46.91	gold quality
ectocervix	UBERON:0012249	46.91	gold quality
muscle of leg	UBERON:0001383	46.63	gold quality
muscle layer of sigmoid colon	UBERON:0035805	46.56	gold quality
kidney	UBERON:0002113	46.49	gold quality
tibial nerve	UBERON:0001323	46.27	gold quality
right lung	UBERON:0002167	46.25	gold quality
gastrocnemius	UBERON:0001388	46.03	gold quality
right coronary artery	UBERON:0001625	45.91	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.78

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.