LINC00452

Summary

LINC00452 (long intergenic non-protein coding RNA 452, HGNC:42800) is a long non-coding RNA gene on chromosome 13q34.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:42800
Approved symbol	LINC00452
Name	long intergenic non-protein coding RNA 452
Location	13q34
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000229373
Ensembl biotype	lncRNA
Entrez	643365
RNAcentral	URS00005580B0 — lncRNA, 1607 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 5 — 5 lncRNA

ENST00000426859, ENST00000671032, ENST00000717692, ENST00000717693, ENST00000717694

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000426859 — 8 exons

Exon	Start	End
ENSE00001596085	113916865	113916944
ENSE00001669853	113915796	113916103
ENSE00001683313	113895103	113895249
ENSE00001692984	113898526	113898687
ENSE00001749434	113921050	113921317
ENSE00003236355	113920723	113920920
ENSE00003246864	113919435	113919654
ENSE00003409202	113901791	113902014

Expression profiles

Bgee: expression breadth broad, 83 present calls, max score 77.33.

Top tissues by expression

186 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	77.33	gold quality
right testis	UBERON:0004534	72.97	gold quality
left testis	UBERON:0004533	72.00	gold quality
testis	UBERON:0000473	69.32	gold quality
sperm	CL:0000019	66.81	gold quality
cortical plate	UBERON:0005343	57.39	silver quality
cerebellar vermis	UBERON:0004720	56.26	gold quality
buccal mucosa cell	CL:0002336	55.44	gold quality
ganglionic eminence	UBERON:0004023	55.06	silver quality
upper leg skin	UBERON:0004262	53.31	silver quality
ascending aorta	UBERON:0001496	52.89	gold quality
stromal cell of endometrium	CL:0002255	52.75	silver quality
hindlimb stylopod muscle	UBERON:0004252	52.50	gold quality
thoracic aorta	UBERON:0001515	52.40	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	51.08	silver quality
metanephros cortex	UBERON:0010533	50.90	gold quality
monocyte	CL:0000576	49.61	silver quality
aorta	UBERON:0000947	49.48	gold quality
right lobe of liver	UBERON:0001114	49.40	silver quality
nipple	UBERON:0002030	49.17	gold quality
muscle of leg	UBERON:0001383	49.14	gold quality
gastrocnemius	UBERON:0001388	48.27	gold quality
ectocervix	UBERON:0012249	48.02	gold quality
cortex of kidney	UBERON:0001225	47.44	gold quality
descending thoracic aorta	UBERON:0002345	46.85	gold quality
islet of Langerhans	UBERON:0000006	46.44	gold quality
thymus	UBERON:0002370	46.31	gold quality
ovary	UBERON:0000992	46.07	gold quality
amniotic fluid	UBERON:0000173	45.25	gold quality
body of pancreas	UBERON:0001150	44.93	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.95

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• LINC00452 promotes ovarian carcinogenesis through increasing ROCK1 by sponging miR-501-3p and suppressing ubiquitin-mediated degradation. (PMID:33168781)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.