LINC00457

Summary

LINC00457 (long intergenic non-protein coding RNA 457, HGNC:42805) is a long non-coding RNA gene on chromosome 13q13.2.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:42805
Approved symbol	LINC00457
Name	long intergenic non-protein coding RNA 457
Location	13q13.2
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000225179
Ensembl biotype	lncRNA
Entrez	100874179
RNAcentral	URS000075B1EE — lncRNA, 416 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 4 — 4 lncRNA

ENST00000428706, ENST00000440160, ENST00000660916, ENST00000664114

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000428706 — 2 exons

Exon	Start	End
ENSE00001622228	34533846	34534195
ENSE00001687610	34534288	34534350

Expression profiles

Bgee: expression breadth broad, 88 present calls, max score 81.23.

Top tissues by expression

88 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	81.23	silver quality
tonsil	UBERON:0002372	75.79	gold quality
ganglionic eminence	UBERON:0004023	59.56	gold quality
monocyte	CL:0000576	59.46	gold quality
placenta	UBERON:0001987	58.96	gold quality
blood	UBERON:0000178	57.65	gold quality
gall bladder	UBERON:0002110	57.65	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	57.42	gold quality
lower esophagus muscularis layer	UBERON:0035833	52.92	gold quality
endometrium	UBERON:0001295	52.64	gold quality
adult mammalian kidney	UBERON:0000082	51.75	gold quality
kidney	UBERON:0002113	51.60	gold quality
prefrontal cortex	UBERON:0000451	51.03	gold quality
vagina	UBERON:0000996	50.98	gold quality
islet of Langerhans	UBERON:0000006	50.88	gold quality
pancreas	UBERON:0001264	48.56	gold quality
corpus callosum	UBERON:0002336	48.32	gold quality
ascending aorta	UBERON:0001496	48.31	gold quality
cortex of kidney	UBERON:0001225	48.20	gold quality
body of pancreas	UBERON:0001150	48.16	gold quality
prostate gland	UBERON:0002367	47.95	gold quality
muscle of leg	UBERON:0001383	47.89	silver quality
heart left ventricle	UBERON:0002084	47.84	gold quality
right atrium auricular region	UBERON:0006631	47.78	gold quality
superior frontal gyrus	UBERON:0002661	47.64	gold quality
caudate nucleus	UBERON:0001873	47.51	gold quality
gastrocnemius	UBERON:0001388	47.20	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	47.14	gold quality
stomach	UBERON:0000945	47.10	gold quality
body of stomach	UBERON:0001161	46.95	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.45

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.