LINC00458

Summary

LINC00458 (long intergenic non-protein coding RNA 458, HGNC:42807) is a long non-coding RNA gene on chromosome 13q14.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:42807
Approved symbol	LINC00458
Name	long intergenic non-protein coding RNA 458
Location	13q14.3
Locus type	RNA, long non-coding
Status	Approved
Aliases	ES3, HBL1, LncRNA-ES3
Ensembl gene	ENSG00000234787
Ensembl biotype	lncRNA
Entrez	100507428
RNAcentral	URS000075E99D — lncRNA, 1059 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 24 — 24 lncRNA

ENST00000423442, ENST00000427299, ENST00000451744, ENST00000606055, ENST00000606706, ENST00000607494, ENST00000666992, ENST00000706980, ENST00000706981, ENST00000706982, ENST00000706983, ENST00000706984, ENST00000706985, ENST00000706986, ENST00000706987, ENST00000706988, ENST00000721162, ENST00000721163, ENST00000721164, ENST00000721165, ENST00000721166, ENST00000721167, ENST00000721168, ENST00000835670

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000423442 — 5 exons

Exon	Start	End
ENSE00001637509	54125149	54125272
ENSE00001664390	54132613	54132866
ENSE00001765368	54112687	54116209
ENSE00003997816	54127280	54127429
ENSE00003997823	54120940	54121044

Expression profiles

Bgee: expression breadth ubiquitous, 156 present calls, max score 79.62.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.5326 / max 72.1413, expressed in 78 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
137436	0.4619	71
137437	0.0707	29

Top tissues by expression

241 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	79.62	gold quality
secondary oocyte	CL:0000655	75.55	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	75.01	gold quality
buccal mucosa cell	CL:0002336	73.70	silver quality
oocyte	CL:0000023	72.92	gold quality
ventricular zone	UBERON:0003053	64.62	gold quality
right atrium auricular region	UBERON:0006631	62.85	gold quality
monocyte	CL:0000576	62.51	gold quality
adrenal tissue	UBERON:0018303	62.33	gold quality
cardiac atrium	UBERON:0002081	62.26	gold quality
ganglionic eminence	UBERON:0004023	60.92	gold quality
calcaneal tendon	UBERON:0003701	60.40	gold quality
cortical plate	UBERON:0005343	59.85	gold quality
corpus callosum	UBERON:0002336	57.80	gold quality
cerebellar hemisphere	UBERON:0002245	57.41	gold quality
cerebellar cortex	UBERON:0002129	57.39	gold quality
right hemisphere of cerebellum	UBERON:0014890	56.59	gold quality
apex of heart	UBERON:0002098	56.25	gold quality
cerebellum	UBERON:0002037	56.19	gold quality
heart	UBERON:0000948	55.28	gold quality
mucosa of transverse colon	UBERON:0004991	54.72	gold quality
right lung	UBERON:0002167	54.67	gold quality
hindlimb stylopod muscle	UBERON:0004252	53.89	gold quality
lower esophagus mucosa	UBERON:0035834	53.39	gold quality
tibial nerve	UBERON:0001323	53.21	gold quality
prefrontal cortex	UBERON:0000451	52.87	gold quality
muscle of leg	UBERON:0001383	52.87	gold quality
right ovary	UBERON:0002118	52.76	gold quality
heart left ventricle	UBERON:0002084	52.65	gold quality
Brodmann (1909) area 9	UBERON:0013540	52.64	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	3.77

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Dynamic changes in LINC00458/HBL1 lncRNA expression during hiPSC differentiation to cardiomyocytes. (PMID:38167488)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.