LINC00460

Summary

LINC00460 (long intergenic non-protein coding RNA 460, HGNC:42809) is a long non-coding RNA gene on chromosome 13q33.2.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:42809
Approved symbol	LINC00460
Name	long intergenic non-protein coding RNA 460
Location	13q33.2
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000233532
Ensembl biotype	lncRNA
Entrez	728192
RNAcentral	URS0000E60AFA — lncRNA, 913 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 8 — 8 lncRNA

ENST00000435024, ENST00000439790, ENST00000444865, ENST00000642946, ENST00000643760, ENST00000644746, ENST00000647525, ENST00000752340

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000435024 — 3 exons

Exon	Start	End
ENSE00001636396	106376867	106377084
ENSE00001669432	106376563	106376665
ENSE00003820206	106377908	106378595

Expression profiles

Bgee: expression breadth broad, 100 present calls, max score 79.19.

FANTOM5 (CAGE): breadth broad, TPM avg 0.9489 / max 634.4843, expressed in 224 samples.

FANTOM5 promoters (8 alternative TSS)

Promoter ID	TPM avg	Samples expressed
135955	0.4734	162
135957	0.2048	32
135958	0.1366	10
135960	0.0564	12
135956	0.0282	8
135959	0.0239	2
207101	0.0199	9
207100	0.0057	2

Top tissues by expression

199 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	79.19	silver quality
caudate nucleus	UBERON:0001873	74.70	gold quality
putamen	UBERON:0001874	74.26	gold quality
prefrontal cortex	UBERON:0000451	72.16	gold quality
nucleus accumbens	UBERON:0001882	70.42	gold quality
anterior cingulate cortex	UBERON:0009835	69.91	gold quality
right hemisphere of cerebellum	UBERON:0014890	68.55	gold quality
right frontal lobe	UBERON:0002810	67.92	gold quality
Brodmann (1909) area 9	UBERON:0013540	67.79	gold quality
frontal cortex	UBERON:0001870	67.74	gold quality
neocortex	UBERON:0001950	67.60	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	67.09	gold quality
bone marrow cell	CL:0002092	66.95	silver quality
amygdala	UBERON:0001876	66.52	gold quality
cerebral cortex	UBERON:0000956	64.82	gold quality
skeletal muscle tissue of biceps brachii	UBERON:0004502	64.82	gold quality
forebrain	UBERON:0001890	64.58	gold quality
cerebellar hemisphere	UBERON:0002245	64.15	gold quality
temporal lobe	UBERON:0001871	63.43	gold quality
brain	UBERON:0000955	63.15	gold quality
stromal cell of endometrium	CL:0002255	61.57	gold quality
quadriceps femoris	UBERON:0001377	61.42	gold quality
vastus lateralis	UBERON:0001379	61.40	gold quality
skeletal muscle tissue of rectus abdominis	UBERON:0004511	60.84	gold quality
Brodmann (1909) area 23	UBERON:0013554	60.41	silver quality
entorhinal cortex	UBERON:0002728	60.31	silver quality
buccal mucosa cell	CL:0002336	59.53	gold quality
epithelium of nasopharynx	UBERON:0001951	59.43	gold quality
superior frontal gyrus	UBERON:0002661	58.57	gold quality
Ammon’s horn	UBERON:0001954	58.49	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	3.76

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 32)

• RNA Linc00460 expression was positively correlated with esophageal squamous cell carcinoma TNM stage, lymph node metastasis, and predicted poor prognosis. (PMID:28939763)
• Study identified a novel cytoplasmic linc00460 that is upregulated in non-small cell lung cancer (NSCLC) tumors, and determined its transcriptional initiation and termination sites. Linc00460 promotes cell migration and invasion through inducing EMT in cancer cells through its direct binding with hnRNPK. These findings suggest that linc00460 acts as an oncogene in NSCLC to promote cell migration. (PMID:29409808)
• LINC00460 promotes MMP-9 expression through targeting miR-539, acting as an oncogenic RNA in the meningeoma malignancy and accelerating the proliferation and metastasis. (PMID:29906745)
• LINC00460 promotes LC progression by competitively binding miR-302c-5p and regulating FOXA1 signal pathway. (PMID:30359741)
• LINC00460 is a new type of molecule involved in the development of GC, which may become a potential target for the treatment of GC. (PMID:30909185)
• LINC00460 and STC2 were highly expressed while miR-206 was poorly expressed in head and neck squamous cell carcinoma . Besides, miR-206 was found to bind to both LINC00460 and STC2. (PMID:31075234)
• this is the first time to examine the potential roles of LINC00460 in lung cancer cell proliferation, migration and apoptosis induced by nicotine. This may help to develop novel therapeutic strategies for the prevention and treatment of metastatic tumors from cigarette smoke-caused lung cancer by blocking the nicotine-activated LINC00460 pathway. (PMID:31123168)
• Downregulated LINC00460 inhibits cell proliferation and promotes cell apoptosis in prostate cancer. (PMID:31364108)
• LINC00460 functioned as an oncogene in NPC which promoted invasion and metastasis. (PMID:31414345)
• High expression of LINC00460 is associated with osteosarcoma progression. (PMID:31419446)
• High LINC00460 expression is associated with epithelial-mesenchymal transition in head and neck squamous cell carcinoma. (PMID:31429766)
• LINC00460 was robustly induced in colorectal cancer. In addition, LINC00460 could down-regulate WWC2 through interaction with ERG, which led to promoted invasion, migration, and EMT of CRC cells in addition to tumor growth in vivo. (PMID:31541369)
• Clinical importance of long noncoding RNA LINC00460 expression in EGFRmutant lung adenocarcinoma. (PMID:31789388)
• Long intergenic nonprotein coding RNA 00460 predicts a poor prognosis and promotes tumorigenesis of human osteosarcoma. (PMID:31974626)
• high LINC00460 expression and low ADAMTS9-AS1 expression in bladder cancer as compared with normal bladder tissues; expression of LINC00460 had no significant correlation with survival (PMID:32277695)
• Long Noncoding RNA LINC00460 Promotes Cell Progression by Sponging miR-4443 in Head and Neck Squamous Cell Carcinoma. (PMID:32478564)
• Long noncoding RNA LINC00460 conduces to tumor growth and metastasis of hepatocellular carcinoma through miR-342-3p-dependent AGR2 up-regulation. (PMID:32493835)
• LncRNA linc00460 sponges miR-1224-5p to promote esophageal cancer metastatic potential and epithelial-mesenchymal transition. (PMID:32534700)
• LINC00460 promotes proliferation and inhibits apoptosis of non-small cell lung cancer cells through targeted regulation of miR-539. (PMID:32633366)
• Long non-coding RNA LINC00460 promotes proliferation and inhibits apoptosis of cervical cancer cells by targeting microRNA-503-5p. (PMID:32740791)
• LINC00460 Enhances Bladder Carcinoma Cell Proliferation and Migration by Modulating miR-612/FOXK1 Axis. (PMID:33027786)
• Downregulation of long non-coding RNA LINC00460 inhibits the proliferation, migration and invasion, and promotes apoptosis of pancreatic cancer cells via modulation of the miR-320b/ARF1 axis. (PMID:33345740)
• lncRNA LINC00460 Functions as a Competing Endogenous RNA and Regulates Expression of BGN by Sponging miR-149-5p in Colorectal Cancer. (PMID:33472555)
• LINC00460/DHX9/IGF2BP2 complex promotes colorectal cancer proliferation and metastasis by mediating HMGA1 mRNA stability depending on m6A modification. (PMID:33526059)
• LINC00460 facilitated tongue squamous cell carcinoma progression via the miR-320b/IGF2BP3 axis. (PMID:33660359)
• LINC00460 promotes pancreatic cancer progression by sponging miR-491-5p. (PMID:33789360)
• Pancreatic ductal adenocarcinoma cells regulated the gemcitabine-resistance function of CAFs by LINC00460. (PMID:36047966)
• LINC00460 Promotes Cutaneous Squamous Cell Carcinoma Progression Through Stabilizing ELAVL1 Protein. (PMID:36513874)
• LINC00460 Facilitates Cell Proliferation and Inhibits Ferroptosis in Breast Cancer Through the miR-320a/MAL2 Axis. (PMID:36938678)
• Long non-coding RNA LINC00460 contributes as a potential prognostic biomarker through its oncogenic role with ANXA2 in colorectal polyps. (PMID:37024747)
• Hypoxia-induced long non-coding RNA LINC00460 promotes p53 mediated proliferation and metastasis of pancreatic cancer by regulating the miR-4689/UBE2V1 axis and sequestering USP10. (PMID:37786443)
• LINC00460 promotes neuroblastoma tumorigenesis and cisplatin resistance by targeting miR-149-5p/DLL1 axis and activating Notch pathway in vitro and in vivo. (PMID:38161194)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.