LINC00466

Summary

LINC00466 (long intergenic non-protein coding RNA 466, HGNC:27294) is a long non-coding RNA gene on chromosome 1p31.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:27294
Approved symbol	LINC00466
Name	long intergenic non-protein coding RNA 466
Location	1p31.3
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000224209
Ensembl biotype	lncRNA
Entrez	199899
RNAcentral	URS0000ABD88D — lncRNA, 1820 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 57 — 56 lncRNA, 1 retained_intron

ENST00000418086, ENST00000432537, ENST00000436475, ENST00000447183, ENST00000455304, ENST00000634576, ENST00000634725, ENST00000635218, ENST00000635458, ENST00000635555, ENST00000653027, ENST00000655035, ENST00000656034, ENST00000656075, ENST00000656229, ENST00000658104, ENST00000658184, ENST00000658957, ENST00000660198, ENST00000662017, ENST00000662911, ENST00000663270, ENST00000664269, ENST00000665381, ENST00000666431, ENST00000666885, ENST00000667005, ENST00000667523, ENST00000667879, ENST00000667957, ENST00000669810, ENST00000671553, ENST00000671620, ENST00000717965, ENST00000717966, ENST00000717969, ENST00000717970, ENST00000717971, ENST00000717972, ENST00000717973, ENST00000717974, ENST00000717975, ENST00000717976, ENST00000717977, ENST00000717978, ENST00000717979, ENST00000717980, ENST00000717981, ENST00000717982, ENST00000717983, ENST00000717984, ENST00000717985, ENST00000717986, ENST00000717987, ENST00000717988, ENST00000717989, ENST00000850654

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000418086 — 2 exons

Exon	Start	End
ENSE00001698708	63261742	63261804
ENSE00004033807	63222885	63223224

Expression profiles

Bgee: expression breadth ubiquitous, 133 present calls, max score 84.37.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.0406 / max 11.7282, expressed in 15 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
12636	0.0406	15

Top tissues by expression

228 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right testis	UBERON:0004534	84.37	gold quality
left testis	UBERON:0004533	83.22	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	82.06	gold quality
testis	UBERON:0000473	80.22	gold quality
sperm	CL:0000019	80.04	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	77.63	gold quality
sural nerve	UBERON:0015488	76.11	gold quality
tibial nerve	UBERON:0001323	69.54	gold quality
tibialis anterior	UBERON:0001385	66.93	silver quality
ileal mucosa	UBERON:0000331	66.49	gold quality
pancreatic ductal cell	CL:0002079	65.19	silver quality
buccal mucosa cell	CL:0002336	64.47	gold quality
ganglionic eminence	UBERON:0004023	59.43	gold quality
cerebellar vermis	UBERON:0004720	58.35	gold quality
ventricular zone	UBERON:0003053	58.28	silver quality
cortical plate	UBERON:0005343	57.76	gold quality
monocyte	CL:0000576	57.49	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	56.42	gold quality
hindlimb stylopod muscle	UBERON:0004252	56.24	gold quality
skin of hip	UBERON:0001554	55.96	silver quality
epithelial cell of pancreas	CL:0000083	55.28	gold quality
muscle layer of sigmoid colon	UBERON:0035805	55.28	gold quality
cardiac muscle of right atrium	UBERON:0003379	54.34	gold quality
left ventricle myocardium	UBERON:0006566	54.23	gold quality
kidney epithelium	UBERON:0004819	53.93	gold quality
skeletal muscle tissue of biceps brachii	UBERON:0004502	53.88	gold quality
islet of Langerhans	UBERON:0000006	53.69	gold quality
upper arm skin	UBERON:0004263	53.52	gold quality
gall bladder	UBERON:0002110	53.46	gold quality
muscle of leg	UBERON:0001383	53.27	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	6.22

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• LINC00466 could restrain the miR-144 expression to up-regulate HOXA10 and, therefore, promote lung adenocarcinoma. (PMID:31381886)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.