LINC00467

Summary

LINC00467 (long intergenic non-protein coding RNA 467, HGNC:28227) is a long non-coding RNA gene on chromosome 1q32.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:28227
Approved symbol	LINC00467
Name	long intergenic non-protein coding RNA 467
Location	1q32.3
Locus type	RNA, long non-coding
Status	Approved
Aliases	MGC14801, ASAP
Ensembl gene	ENSG00000153363
Ensembl biotype	lncRNA
OMIM	620079
Entrez	84791
RNAcentral	URS000075ACB7 — lncRNA, 797 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 33 — 33 lncRNA

ENST00000423222, ENST00000448567, ENST00000534914, ENST00000610948, ENST00000653287, ENST00000653498, ENST00000653721, ENST00000654699, ENST00000654903, ENST00000656082, ENST00000656159, ENST00000656886, ENST00000657539, ENST00000659698, ENST00000660130, ENST00000660843, ENST00000661331, ENST00000662409, ENST00000662549, ENST00000663427, ENST00000663693, ENST00000664255, ENST00000665802, ENST00000666134, ENST00000667464, ENST00000669618, ENST00000670353, ENST00000689408, ENST00000703046, ENST00000818500, ENST00000818501, ENST00000818502, ENST00000818503

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000423222 — 6 exons

Exon	Start	End
ENSE00001794767	211426211	211426283
ENSE00003729521	211391827	211391976
ENSE00003730834	211396767	211396831
ENSE00003734384	211391616	211391697
ENSE00004222552	211382727	211382925
ENSE00004222559	211432319	211435333

Expression profiles

Bgee: expression breadth ubiquitous, 236 present calls, max score 99.67.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 13.7135 / max 569.7203, expressed in 1792 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
8425	13.7135	1792

Top tissues by expression

247 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sperm	CL:0000019	99.67	gold quality
left testis	UBERON:0004533	99.45	gold quality
right testis	UBERON:0004534	99.28	gold quality
testis	UBERON:0000473	97.55	gold quality
adult organism	UBERON:0007023	97.06	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	91.63	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	89.56	gold quality
corpus epididymis	UBERON:0004359	87.39	gold quality
islet of Langerhans	UBERON:0000006	87.25	gold quality
sural nerve	UBERON:0015488	86.78	gold quality
caput epididymis	UBERON:0004358	85.71	gold quality
epithelial cell of pancreas	CL:0000083	84.32	silver quality
adrenal tissue	UBERON:0018303	84.08	gold quality
right adrenal gland	UBERON:0001233	83.99	gold quality
right adrenal gland cortex	UBERON:0035827	83.93	gold quality
left adrenal gland	UBERON:0001234	83.66	gold quality
left adrenal gland cortex	UBERON:0035825	83.30	gold quality
pancreas	UBERON:0001264	83.27	gold quality
adrenal gland	UBERON:0002369	82.92	gold quality
right lobe of liver	UBERON:0001114	82.75	gold quality
adrenal cortex	UBERON:0001235	82.57	gold quality
calcaneal tendon	UBERON:0003701	82.57	gold quality
bronchial epithelial cell	CL:0002328	82.49	gold quality
metanephros cortex	UBERON:0010533	82.44	gold quality
endothelial cell	CL:0000115	82.18	gold quality
body of pancreas	UBERON:0001150	82.04	gold quality
liver	UBERON:0002107	81.76	gold quality
bronchus	UBERON:0002185	81.47	gold quality
cauda epididymis	UBERON:0004360	81.28	gold quality
right uterine tube	UBERON:0001302	81.15	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	9.33

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 27)

• N-Myc-mediated suppression of linc00467 gene transcription counterintuitively blocks N-Myc-mediated reduction in RD3 mRNA expression, and reduces neuroblastoma cell survival by inducing DKK1 expression (PMID:24586304)
• LINC00467 epigenetically silenced DKK1 by recruiting enhancer of zeste 2 polycomb repressive complex 2 subunit (EZH2) to DKK1 promoter. (PMID:31027730)
• LINC00467 expression was upregulated in human lung tumour tissues compared with normal tissues. (PMID:31180543)
• LINC00467 silencing or miR-107 up-regulation repressed tumorigenic ability in xenograft tumor-bearing nude mice in cervical cancer in vivo. LINC00467 silencing or miR-107 up-regulation may serve as novel potential strategies for the treatment of cervical cancer. (PMID:31640853)
• LINC00467 promotes cell proliferation and metastasis by binding with IGF2BP3 to enhance the mRNA stability of TRAF5 in hepatocellular carcinoma. (PMID:31656043)
• Ferritin Light Chain (FTL) competes with long noncoding RNA Linc00467 for miR-133b binding site to regulate chemoresistance and metastasis of colorectal cancer. (PMID:31675755)
• Long noncoding RNA linc00467 plays an oncogenic role in hepatocellular carcinoma by regulating the miR-18a-5p/NEDD9 axis. (PMID:31916278)
• LINC00467 promotes proliferation and invasion in glioma via interacting with miRNA-485-5p. (PMID:32016980)
• Long non-coding RNA LINC00467 drives hepatocellular carcinoma progression via inhibiting NR4A3. (PMID:32125766)
• LINC00467 enhances head and neck squamous cell carcinoma progression and the epithelial-mesenchymal transition process via miR-299-5p/ubiquitin specific protease-48 axis. (PMID:32159247)
• LINC00467 knockdown repressed cell proliferation but stimulated cell apoptosis in glioblastoma via miR-339-3p/IP6K2 axis. (PMID:32176627)
• Knockdown of LINC00467 contributed to Axitinib sensitivity in hepatocellular carcinoma through miR-509-3p/PDGFRA axis. (PMID:32221502)
• The Rs12569232 SNP Association with Vogt-Koyanagi-Harada Disease and Behcet’s Disease is Probably Mediated by Regulation of Linc00467 Expression. (PMID:32400232)
• LncRNA LINC00467 contributes to osteosarcoma growth and metastasis through regulating HMGA1 by directly targeting miR-217. (PMID:32572906)
• reveals the biological function of linc00467 to promote the resistance to adriamycin in acute myeloid leukemia (PMID:32669170)
• Knockdown of long non-coding RNA LINC00467 inhibits glioma cell progression via modulation of E2F3 targeted by miR-200a. (PMID:32684096)
• LncRNA LINC00467 acted as an oncogene in esophageal squamous cell carcinoma by accelerating cell proliferation and preventing cell apoptosis via the miR-485-5p/DPAGT1 axis. (PMID:32720371)
• LINC00467 facilitates osteosarcoma progression by sponging miR217 to regulate KPNA4 expression. (PMID:33537823)
• Overexpressed LINC00467 promotes the viability and proliferation yet inhibits apoptosis of gastric cancer cells via raising ITGB3 level. (PMID:34555778)
• Micropeptide ASAP encoded by LINC00467 promotes colorectal cancer progression by directly modulating ATP synthase activity. (PMID:34591791)
• Linc00467 promotion of gastric cancer development by directly regulating miR-7-5p expression and downstream epidermal growth factor receptor. (PMID:34713767)
• LINC00467 Is Upregulated by DNA Copy Number Amplification and Hypomethylation and Shows ceRNA Potential in Lung Adenocarcinoma. (PMID:35095769)
• LINC00467 facilitates the proliferation, migration and invasion of glioma via promoting the expression of inositol hexakisphosphate kinase 2 by binding to miR-339-3p. (PMID:35156508)
• Downregulated Reprimo by LINC00467 participates in the growth and metastasis of gastric cancer. (PMID:35549646)
• Silencing of LINC00467 inhibits cell proliferation in testicular germ cell tumors cells. (PMID:37078359)
• LINC00467 mediates the 5-fluorouracil resistance in breast cancer cells. (PMID:38127229)
• LINC00467 enhanced the proliferative, migratory and invasive ability of breast cancer cells by targeting miR-18a/b-5p/MAPK4 axis. (PMID:38279470)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.