LINC00470

Summary

LINC00470 (long intergenic non-protein coding RNA 470, HGNC:1225) is a long non-coding RNA gene on chromosome 18p11.32.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:1225
Approved symbol	LINC00470
Name	long intergenic non-protein coding RNA 470
Location	18p11.32
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000132204
Ensembl biotype	lncRNA
Entrez	56651
RNAcentral	URS000075E746 — lncRNA, 2231 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 77 — 77 lncRNA

ENST00000412816, ENST00000577403, ENST00000577867, ENST00000578835, ENST00000580336, ENST00000581212, ENST00000581430, ENST00000582570, ENST00000582862, ENST00000584090, ENST00000584492, ENST00000653213, ENST00000653775, ENST00000654559, ENST00000655957, ENST00000657121, ENST00000657423, ENST00000657618, ENST00000657919, ENST00000658090, ENST00000659094, ENST00000659289, ENST00000660358, ENST00000660475, ENST00000660947, ENST00000660964, ENST00000661233, ENST00000661646, ENST00000661852, ENST00000661931, ENST00000663392, ENST00000663512, ENST00000665133, ENST00000666542, ENST00000667225, ENST00000667416, ENST00000667776, ENST00000669153, ENST00000669242, ENST00000669312, ENST00000671558, ENST00000671645, ENST00000753544, ENST00000753545, ENST00000753546, ENST00000753547, ENST00000753548, ENST00000753549, ENST00000753550, ENST00000753551, ENST00000753552, ENST00000753553, ENST00000753554, ENST00000753555, ENST00000753556, ENST00000753557, ENST00000753558, ENST00000753559, ENST00000753560, ENST00000753561, ENST00000753562, ENST00000753563, ENST00000753564, ENST00000753565, ENST00000753566, ENST00000753567, ENST00000753568, ENST00000753569, ENST00000753570, ENST00000753571, ENST00000753572, ENST00000753573, ENST00000753574, ENST00000753575, ENST00000753576, ENST00000753577, ENST00000753578

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000412816 — 5 exons

Exon	Start	End
ENSE00002726468	1368485	1368597
ENSE00003640804	1275966	1276077
ENSE00003671679	1272442	1272511
ENSE00004100835	1268311	1269852
ENSE00004100844	1406987	1407246

Expression profiles

Bgee: expression breadth ubiquitous, 157 present calls, max score 93.91.

Top tissues by expression

241 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
buccal mucosa cell	CL:0002336	93.91	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	87.12	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	86.97	gold quality
sperm	CL:0000019	85.14	gold quality
endothelial cell	CL:0000115	82.89	gold quality
placenta	UBERON:0001987	81.02	gold quality
testis	UBERON:0000473	73.35	gold quality
left testis	UBERON:0004533	72.76	gold quality
right testis	UBERON:0004534	72.75	gold quality
kidney epithelium	UBERON:0004819	72.16	gold quality
pancreatic ductal cell	CL:0002079	68.71	silver quality
epithelial cell of pancreas	CL:0000083	68.51	gold quality
adrenal tissue	UBERON:0018303	66.56	gold quality
liver	UBERON:0002107	65.92	gold quality
sural nerve	UBERON:0015488	65.75	gold quality
right lobe of liver	UBERON:0001114	65.32	gold quality
ileal mucosa	UBERON:0000331	65.13	silver quality
tibialis anterior	UBERON:0001385	64.88	silver quality
ganglionic eminence	UBERON:0004023	64.54	gold quality
upper arm skin	UBERON:0004263	64.46	gold quality
ventricular zone	UBERON:0003053	61.93	gold quality
cortical plate	UBERON:0005343	61.50	gold quality
mucosa of transverse colon	UBERON:0004991	61.00	gold quality
monocyte	CL:0000576	60.49	gold quality
secondary oocyte	CL:0000655	59.64	gold quality
lower esophagus mucosa	UBERON:0035834	59.59	gold quality
hindlimb stylopod muscle	UBERON:0004252	59.30	gold quality
oocyte	CL:0000023	57.28	gold quality
cardiac muscle of right atrium	UBERON:0003379	55.54	gold quality
left ventricle myocardium	UBERON:0006566	54.23	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	5.19

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 6)

• LncRNA LINC00470 promotes proliferation through association with NF45/NF90 complex in hepatocellular carcinoma. (PMID:31612313)
• LINC00470 is upregulated in the gastric cancer tissues and promotes GC cell proliferation, migration and invasion.LINC00470 associated with PTEN mRNA and suppressed its stability through interaction with the N(6)-methyladenosine (m(6)A) writer METTL3. (PMID:31711642)
• LINC00470 promotes tumour proliferation and invasion, and attenuates chemosensitivity through the LINC00470/miR-134/Myc/ABCC1 axis in glioma. (PMID:32916774)
• Dysregulation of LINC00470 and METTL3 promotes chemoresistance and suppresses autophagy of chronic myelocytic leukaemia cells. (PMID:33749070)
• LINC00470 accelerates the proliferation and metastasis of melanoma through promoting APEX1 expression. (PMID:33875645)
• Temozolomide protects against the progression of glioblastoma via SOX4 downregulation by inhibiting the LINC00470-mediated transcription factor EGR2. (PMID:36987665)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.