LINC00486

Summary

LINC00486 (long intergenic non-protein coding RNA 486, HGNC:42946) is a long non-coding RNA gene on chromosome 2p22.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:42946
Approved symbol	LINC00486
Name	long intergenic non-protein coding RNA 486
Location	2p22.3
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000230876
Ensembl biotype	lncRNA
Entrez	285045
RNAcentral	URS0000EED4D3 — lncRNA, 2141 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 12 — 12 lncRNA

ENST00000414054, ENST00000424364, ENST00000435075, ENST00000648808, ENST00000654101, ENST00000657199, ENST00000663645, ENST00000663772, ENST00000717228, ENST00000717229, ENST00000717230, ENST00000717231

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000414054 — 5 exons

Exon	Start	End
ENSE00001597870	32925353	32926693
ENSE00001611125	32902063	32902123
ENSE00001663452	32825443	32825510
ENSE00001745142	32898540	32898642
ENSE00003887347	32841013	32841233

Expression profiles

Bgee: expression breadth ubiquitous, 123 present calls, max score 79.29.

Top tissues by expression

216 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	79.29	silver quality
sural nerve	UBERON:0015488	66.54	gold quality
putamen	UBERON:0001874	64.21	gold quality
amygdala	UBERON:0001876	62.77	gold quality
ganglionic eminence	UBERON:0004023	61.84	gold quality
prefrontal cortex	UBERON:0000451	60.74	gold quality
ventricular zone	UBERON:0003053	60.13	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	59.26	gold quality
caudate nucleus	UBERON:0001873	58.23	gold quality
cortical plate	UBERON:0005343	57.69	silver quality
Brodmann (1909) area 9	UBERON:0013540	57.56	gold quality
spinal cord	UBERON:0002240	57.52	gold quality
substantia nigra	UBERON:0002038	57.25	gold quality
nucleus accumbens	UBERON:0001882	56.65	gold quality
hypothalamus	UBERON:0001898	56.35	gold quality
midbrain	UBERON:0001891	55.13	gold quality
monocyte	CL:0000576	55.07	gold quality
right frontal lobe	UBERON:0002810	54.83	gold quality
frontal cortex	UBERON:0001870	54.72	gold quality
corpus callosum	UBERON:0002336	54.29	gold quality
Ammon’s horn	UBERON:0001954	54.26	gold quality
leukocyte	CL:0000738	54.06	gold quality
neocortex	UBERON:0001950	53.78	gold quality
forebrain	UBERON:0001890	53.32	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	53.13	gold quality
temporal lobe	UBERON:0001871	53.08	gold quality
brain	UBERON:0000955	52.65	gold quality
cerebral cortex	UBERON:0000956	52.49	gold quality
anterior cingulate cortex	UBERON:0009835	51.67	gold quality
heart left ventricle	UBERON:0002084	51.56	gold quality

Single-cell (SCXA)

Detected in 3 experiment(s), a significant marker in 2.

Experiment	Marker?	Max mean expression
E-GEOD-180759	yes	4427.23
E-ANND-3	yes	3.75
E-MTAB-11268	no	2812.81

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.