LINC00488

Summary

LINC00488 (long intergenic non-protein coding RNA 488, HGNC:32675) is a long non-coding RNA gene on chromosome 3q13.13.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32675
Approved symbol	LINC00488
Name	long intergenic non-protein coding RNA 488
Location	3q13.13
Locus type	RNA, long non-coding
Status	Approved
Aliases	FLJ41232
Ensembl gene	ENSG00000214381
Ensembl biotype	lncRNA
Entrez	677779
RNAcentral	URS000075D0F4 — lncRNA, 2524 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 7 — 6 lncRNA, 1 retained_intron

ENST00000494582, ENST00000648541, ENST00000743424, ENST00000743425, ENST00000743426, ENST00000743427, ENST00000743428

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000494582 — 3 exons

Exon	Start	End
ENSE00001880810	109178417	109178568
ENSE00004081811	109183021	109185257
ENSE00004081813	109178060	109178295

Expression profiles

Bgee: expression breadth broad, 55 present calls, max score 77.37.

Top tissues by expression

185 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	77.37	silver quality
prefrontal cortex	UBERON:0000451	56.84	gold quality
metanephros cortex	UBERON:0010533	56.13	gold quality
anterior cingulate cortex	UBERON:0009835	52.12	gold quality
nucleus accumbens	UBERON:0001882	51.32	gold quality
monocyte	CL:0000576	51.00	silver quality
right hemisphere of cerebellum	UBERON:0014890	50.93	gold quality
neocortex	UBERON:0001950	50.35	gold quality
frontal cortex	UBERON:0001870	50.29	gold quality
metanephros	UBERON:0000081	49.94	gold quality
cerebellar hemisphere	UBERON:0002245	48.86	gold quality
testis	UBERON:0000473	48.67	gold quality
Brodmann (1909) area 9	UBERON:0013540	47.57	gold quality
cortex of kidney	UBERON:0001225	47.36	gold quality
cerebral cortex	UBERON:0000956	47.20	gold quality
right frontal lobe	UBERON:0002810	46.61	gold quality
amygdala	UBERON:0001876	46.45	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	46.44	gold quality
adult mammalian kidney	UBERON:0000082	46.41	gold quality
forebrain	UBERON:0001890	46.11	gold quality
gastrocnemius	UBERON:0001388	45.87	silver quality
brain	UBERON:0000955	45.71	gold quality
islet of Langerhans	UBERON:0000006	45.64	silver quality
hypothalamus	UBERON:0001898	45.21	gold quality
small intestine	UBERON:0002108	45.20	gold quality
kidney	UBERON:0002113	44.96	gold quality
duodenum	UBERON:0002114	44.73	gold quality
upper lobe of lung	UBERON:0008948	44.45	silver quality
lower lobe of lung	UBERON:0008949	44.41	silver quality
transverse colon	UBERON:0001157	44.19	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	4.44

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 3)

• lncRNA LINC00488 can competitively sponge miR-330-5p to regulate TLN1 in relation to the cell growth and angiogenesis in hepatocellular carcinoma. (PMID:31005556)
• Long non-coding RNA LINC00488 facilitates thyroid cancer cell progression through miR-376a-3p/PON2. (PMID:33600548)
• LINC00488 Induces Tumorigenicity in Retinoblastoma by Regulating microRNA-30a-5p/EPHB2 Axis. (PMID:35404750)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.