LINC00491

Summary

LINC00491 (long intergenic non-protein coding RNA 491, HGNC:43428) is a long non-coding RNA gene on chromosome 5q21.1.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:43428
Approved symbol	LINC00491
Name	long intergenic non-protein coding RNA 491
Location	5q21.1
Locus type	RNA, long non-coding
Status	Approved
Aliases	BC008363
Ensembl gene	ENSG00000250682
Ensembl biotype	lncRNA
Entrez	285708
RNAcentral	URS0000759FEF — lncRNA, 1662 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 16 — 16 lncRNA

ENST00000505527, ENST00000508339, ENST00000510145, ENST00000513815, ENST00000658823, ENST00000660106, ENST00000662437, ENST00000669204, ENST00000670038, ENST00000769651, ENST00000769652, ENST00000769653, ENST00000769654, ENST00000769655, ENST00000769656, ENST00000769657

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000505527 — 4 exons

Exon	Start	End
ENSE00002026429	102611893	102611955
ENSE00002030173	102617858	102617928
ENSE00004130969	102671227	102671322
ENSE00004130970	102608482	102609766

Expression profiles

Bgee: expression breadth ubiquitous, 119 present calls, max score 96.01.

Top tissues by expression

195 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
cardia of stomach	UBERON:0001162	96.01	silver quality
caecum	UBERON:0001153	93.15	silver quality
ventral tegmental area	UBERON:0002691	91.11	silver quality
superficial temporal artery	UBERON:0001614	90.16	gold quality
superior vestibular nucleus	UBERON:0007227	90.12	silver quality
body of tongue	UBERON:0011876	89.83	gold quality
vena cava	UBERON:0004087	89.27	gold quality
medulla oblongata	UBERON:0001896	89.18	silver quality
mucosa of paranasal sinus	UBERON:0005030	89.11	gold quality
superior surface of tongue	UBERON:0007371	88.88	silver quality
dorsal root ganglion	UBERON:0000044	88.46	silver quality
pons	UBERON:0000988	88.41	gold quality
dorsal plus ventral thalamus	UBERON:0001897	88.06	silver quality
cerebellar vermis	UBERON:0004720	87.46	gold quality
pericardium	UBERON:0002407	86.43	gold quality
trachea	UBERON:0003126	85.84	silver quality
nipple	UBERON:0002030	85.53	gold quality
renal medulla	UBERON:0000362	82.89	gold quality
pylorus	UBERON:0001166	82.77	gold quality
mammary duct	UBERON:0001765	82.60	gold quality
lateral globus pallidus	UBERON:0002476	80.23	gold quality
lateral nuclear group of thalamus	UBERON:0002736	78.38	gold quality
gingival epithelium	UBERON:0001949	77.89	gold quality
thymus	UBERON:0002370	77.62	gold quality
lower lobe of lung	UBERON:0008949	77.01	silver quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	76.59	gold quality
skeletal muscle tissue of rectus abdominis	UBERON:0004511	76.35	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	76.28	gold quality
substantia nigra pars reticulata	UBERON:0001966	76.26	gold quality
substantia nigra pars compacta	UBERON:0001965	75.91	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.10

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 4)

• Long noncoding RNA LINC00491 promotes proliferation and inhibits apoptosis in esophageal squamous cell carcinoma. (PMID:33537830)
• LINC00491 promotes cell growth and metastasis through miR-324-5p/ROCK1 in liver cancer. (PMID:34876144)
• Silencing LINC00491 inhibits prostate cancer development through the miR-384/TRIM44 axis. (PMID:37070216)
• Long non-coding RNA LINC00491 accelerates head and neck squamous cell carcinoma progression through regulating miR-508-3p/SATB1 axis and activating Wnt signaling pathway. (PMID:38150791)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.