LINC00498

Summary

LINC00498 (long intergenic non-protein coding RNA 498, HGNC:43435) is a long non-coding RNA gene on chromosome 4q28.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:43435
Approved symbol	LINC00498
Name	long intergenic non-protein coding RNA 498
Location	4q28.3
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000248397
Ensembl biotype	lncRNA
Entrez	105377446
RNAcentral	URS0002A4704D — lncRNA, 810 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 7 — 7 lncRNA

ENST00000504369, ENST00000507220, ENST00000751419, ENST00000751420, ENST00000751421, ENST00000751422, ENST00000751423

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000504369 — 3 exons

Exon	Start	End
ENSE00004096681	138312294	138312690
ENSE00004096686	138298852	138298945
ENSE00004096688	138298473	138298658

Expression profiles

Bgee: expression breadth broad, 70 present calls, max score 91.78.

Top tissues by expression

70 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	91.78	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	89.39	gold quality
islet of Langerhans	UBERON:0000006	62.80	gold quality
bone marrow	UBERON:0002371	57.57	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	55.50	gold quality
superior frontal gyrus	UBERON:0002661	54.87	gold quality
prefrontal cortex	UBERON:0000451	54.52	gold quality
blood	UBERON:0000178	54.08	gold quality
left testis	UBERON:0004533	53.59	gold quality
testis	UBERON:0000473	53.50	gold quality
calcaneal tendon	UBERON:0003701	53.22	gold quality
right testis	UBERON:0004534	51.42	gold quality
monocyte	CL:0000576	51.40	silver quality
muscle of leg	UBERON:0001383	51.06	gold quality
left ovary	UBERON:0002119	50.83	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	50.08	gold quality
amygdala	UBERON:0001876	50.01	gold quality
gastrocnemius	UBERON:0001388	49.93	gold quality
endometrium	UBERON:0001295	48.88	silver quality
putamen	UBERON:0001874	48.56	gold quality
heart left ventricle	UBERON:0002084	47.82	gold quality
anterior cingulate cortex	UBERON:0009835	47.31	gold quality
left lobe of thyroid gland	UBERON:0001120	46.81	gold quality
heart	UBERON:0000948	46.66	gold quality
frontal cortex	UBERON:0001870	46.63	gold quality
brain	UBERON:0000955	46.61	gold quality
caudate nucleus	UBERON:0001873	46.44	gold quality
substantia nigra	UBERON:0002038	46.34	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	46.30	gold quality
ovary	UBERON:0000992	46.13	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.80

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.