LINC00501

Summary

LINC00501 (long intergenic non-protein coding RNA 501, HGNC:43439) is a long non-coding RNA gene on chromosome 3q26.32.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:43439
Approved symbol	LINC00501
Name	long intergenic non-protein coding RNA 501
Location	3q26.32
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000203645
Ensembl biotype	lncRNA
Entrez	100820709
RNAcentral	URS000075A51A — lncRNA, 2063 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 9 — 9 lncRNA

ENST00000425388, ENST00000754915, ENST00000754916, ENST00000754917, ENST00000754918, ENST00000754919, ENST00000754920, ENST00000754921, ENST00000754922

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000425388 — 2 exons

Exon	Start	End
ENSE00004103346	177294378	177294497
ENSE00004103354	177321429	177323423

Expression profiles

Bgee: expression breadth broad, 87 present calls, max score 81.92.

Top tissues by expression

87 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	81.92	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	78.12	gold quality
right lobe of liver	UBERON:0001114	61.21	gold quality
ventricular zone	UBERON:0003053	58.53	silver quality
mucosa of transverse colon	UBERON:0004991	58.53	gold quality
cortical plate	UBERON:0005343	58.20	silver quality
ganglionic eminence	UBERON:0004023	57.91	gold quality
heart left ventricle	UBERON:0002084	57.50	gold quality
rectum	UBERON:0001052	56.95	gold quality
duodenum	UBERON:0002114	55.81	gold quality
transverse colon	UBERON:0001157	53.69	gold quality
heart	UBERON:0000948	53.48	gold quality
apex of heart	UBERON:0002098	53.29	gold quality
placenta	UBERON:0001987	52.59	gold quality
stromal cell of endometrium	CL:0002255	52.56	silver quality
cortex of kidney	UBERON:0001225	52.56	gold quality
blood	UBERON:0000178	52.35	silver quality
colon	UBERON:0001155	51.59	gold quality
intestine	UBERON:0000160	51.57	gold quality
prefrontal cortex	UBERON:0000451	51.28	silver quality
kidney	UBERON:0002113	51.05	gold quality
small intestine	UBERON:0002108	50.94	gold quality
adult mammalian kidney	UBERON:0000082	50.85	gold quality
small intestine Peyer’s patch	UBERON:0003454	50.35	gold quality
body of pancreas	UBERON:0001150	50.05	silver quality
lung	UBERON:0002048	48.43	silver quality
metanephros cortex	UBERON:0010533	47.82	gold quality
right lobe of thyroid gland	UBERON:0001119	47.78	gold quality
superior frontal gyrus	UBERON:0002661	47.68	silver quality
vermiform appendix	UBERON:0001154	47.10	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	2.77

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• The LINC00501-HSP90B1-STAT3 positive feedback loop promotes malignant behavior in gastric cancer cells. (PMID:37156452)
• Upregulation of LINC00501 by H3K27 acetylation facilitates gastric cancer metastasis through activating epithelial-mesenchymal transition and angiogenesis. (PMID:37867401)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.