LINC00504

Summary

LINC00504 (long intergenic non-protein coding RNA 504, HGNC:43555) is a long non-coding RNA gene on chromosome 4p15.33.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:43555
Approved symbol	LINC00504
Name	long intergenic non-protein coding RNA 504
Location	4p15.33
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000248360
Ensembl biotype	lncRNA
Entrez	201853
RNAcentral	URS000054D0A9 — lncRNA, 4672 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 4 — 4 lncRNA

ENST00000505089, ENST00000506292, ENST00000509654, ENST00000515031

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000505089 — 7 exons

Exon	Start	End
ENSE00001624320	14614280	14614416
ENSE00002029407	14859543	14859616
ENSE00002061625	14888059	14888169
ENSE00002079684	14700743	14700781
ENSE00002380300	14572147	14572246
ENSE00002425101	14477347	14477458
ENSE00003705428	14470465	14474563

Expression profiles

Bgee: expression breadth ubiquitous, 144 present calls, max score 97.40.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.2858 / max 81.5612, expressed in 63 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
51433	0.2858	63

Top tissues by expression

236 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	97.40	gold quality
colonic epithelium	UBERON:0000397	80.52	gold quality
bone marrow cell	CL:0002092	74.95	gold quality
cortical plate	UBERON:0005343	65.98	gold quality
sperm	CL:0000019	64.50	gold quality
tonsil	UBERON:0002372	62.01	gold quality
calcaneal tendon	UBERON:0003701	61.48	gold quality
skin of leg	UBERON:0001511	59.85	gold quality
ventricular zone	UBERON:0003053	59.38	silver quality
skin of abdomen	UBERON:0001416	59.14	gold quality
descending thoracic aorta	UBERON:0002345	58.67	gold quality
ganglionic eminence	UBERON:0004023	58.55	gold quality
lower lobe of lung	UBERON:0008949	57.76	silver quality
uterine cervix	UBERON:0000002	57.71	gold quality
zone of skin	UBERON:0000014	57.70	gold quality
monocyte	CL:0000576	56.45	gold quality
leukocyte	CL:0000738	56.05	gold quality
thoracic aorta	UBERON:0001515	55.78	gold quality
ascending aorta	UBERON:0001496	55.61	gold quality
hindlimb stylopod muscle	UBERON:0004252	54.49	gold quality
lower esophagus mucosa	UBERON:0035834	54.02	gold quality
prefrontal cortex	UBERON:0000451	53.72	gold quality
aorta	UBERON:0000947	52.39	gold quality
liver	UBERON:0002107	52.28	gold quality
right coronary artery	UBERON:0001625	50.97	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	50.38	gold quality
bone marrow	UBERON:0002371	50.29	silver quality
adrenal gland	UBERON:0002369	50.17	gold quality
skeletal muscle tissue	UBERON:0001134	49.77	gold quality
islet of Langerhans	UBERON:0000006	49.75	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	5.10

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 5)

• A noncoding RNA LINC00504 interacts with c-Myc to regulate tumor metabolism in colon cancer. (PMID:30998289)
• study shows that LINC00504 promotes Ovarian cancer (OC) cell progression and stimulates aerobic glycolysis by interacting with miR-1244, which indicates that LINC00504 might act as a promising therapeutic target for OC treatment (PMID:31691157)
• Upregulation of LINC00504 is associated with aggressive progression and poor prognosis in non-small cell lung cancer. (PMID:32016971)
• Novel lncRNAs Co-Expression Networks Identifies LINC00504 with Oncogenic Role in Luminal A Breast Cancer Cells. (PMID:33670895)
• LINC00504 promotes the progression of acute myeloid leukemia by targeting MDM2. (PMID:36812228)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.