LINC00518

Summary

LINC00518 (long intergenic non-protein coding RNA 518, HGNC:28626) is a long non-coding RNA gene on chromosome 6p24.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:28626
Approved symbol	LINC00518
Name	long intergenic non-protein coding RNA 518
Location	6p24.3
Locus type	RNA, long non-coding
Status	Approved
Aliases	MGC40222, LENOX
Ensembl gene	ENSG00000183674
Ensembl biotype	lncRNA
Entrez	221718
RNAcentral	URS000075AEC3 — lncRNA, 3018 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 19 — 19 lncRNA

ENST00000420389, ENST00000472178, ENST00000479822, ENST00000487130, ENST00000491317, ENST00000496285, ENST00000655125, ENST00000656574, ENST00000662081, ENST00000741652, ENST00000741660, ENST00000741884, ENST00000741885, ENST00000741886, ENST00000741887, ENST00000742426, ENST00000742427, ENST00000742428, ENST00000742429

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000420389 — 3 exons

Exon	Start	End
ENSE00001634310	10424758	10424852
ENSE00001701886	10423140	10423503
ENSE00001732750	10426097	10426176

Expression profiles

Bgee: expression breadth broad, 60 present calls, max score 95.98.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.6817 / max 200.3713, expressed in 69 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
71689	0.6753	69
203855	0.0064	1

Top tissues by expression

172 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	95.98	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	82.69	gold quality
buccal mucosa cell	CL:0002336	78.81	gold quality
sperm	CL:0000019	73.91	silver quality
tibialis anterior	UBERON:0001385	63.35	silver quality
pancreatic ductal cell	CL:0002079	59.59	silver quality
ileal mucosa	UBERON:0000331	57.53	silver quality
ganglionic eminence	UBERON:0004023	57.26	gold quality
epithelial cell of pancreas	CL:0000083	54.60	gold quality
cardiac muscle of right atrium	UBERON:0003379	54.34	gold quality
left ventricle myocardium	UBERON:0006566	54.23	gold quality
kidney epithelium	UBERON:0004819	53.93	gold quality
upper arm skin	UBERON:0004263	53.52	gold quality
muscle of leg	UBERON:0001383	52.07	silver quality
skin of abdomen	UBERON:0001416	51.18	gold quality
myocardium	UBERON:0002349	50.25	gold quality
monocyte	CL:0000576	50.21	silver quality
gastrocnemius	UBERON:0001388	49.93	silver quality
skin of leg	UBERON:0001511	49.60	gold quality
right atrium auricular region	UBERON:0006631	49.49	gold quality
skin of hip	UBERON:0001554	49.34	silver quality
zone of skin	UBERON:0000014	49.12	gold quality
islet of Langerhans	UBERON:0000006	48.59	gold quality
pancreas	UBERON:0001264	47.71	silver quality
quadriceps femoris	UBERON:0001377	47.63	gold quality
prefrontal cortex	UBERON:0000451	47.04	gold quality
nasal cavity epithelium	UBERON:0005384	47.03	gold quality
ascending aorta	UBERON:0001496	46.78	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	46.44	silver quality
ovary	UBERON:0000992	46.39	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.29

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 9)

• Linc00518 knockdown enhanced chemosensitivity to adriamycin (ADR), vincristine (VCR) and paclitaxel (PTX), and boosted ADR-, VCR- and PTX-induced apoptosis in ADR-resistant MCF-7 cells. (PMID:30001527)
• overexpression of Linc00518 contributed to the paclitaxel resistance in prostate cancer via sequestering miR-216b-5p. (PMID:30462844)
• Down-regulation of LINC00518 might have the ability to suppress Breast cancer progression by up-regulating CDX2 expression through the reduction of methylation and blockade of the Wnt signaling pathway, resulting in the inhibition of proliferation and promotion of apoptosis of BC epithelial cells. (PMID:30611858)
• Knockdown of long non-coding RNA LINC00518 inhibits cervical cancer proliferation and metastasis by modulating JAK/STAT3 signaling. (PMID:30720156)
• Long noncoding RNA LINC00518 acts as a competing endogenous RNA to promote the metastasis of malignant melanoma via miR-204-5p/AP1S2 axis. (PMID:31712557)
• LncRNA LINC00518 Acts as an Oncogene in Uveal Melanoma by Regulating an RNA-Based Network. (PMID:33371395)
• Long noncoding RNA LINC00518 induces radioresistance by regulating glycolysis through an miR-33a-3p/HIF-1alpha negative feedback loop in melanoma. (PMID:33664256)
• The LncRNA LENOX Interacts with RAP2C to Regulate Metabolism and Promote Resistance to MAPK Inhibition in Melanoma. (PMID:36214632)
• LINC00518: a key player in tumor progression and clinical outcomes. (PMID:39108268)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.