LINC00520

Summary

LINC00520 (long intergenic non-protein coding RNA 520, HGNC:19843) is a long non-coding RNA gene on chromosome 14q22.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:19843
Approved symbol	LINC00520
Name	long intergenic non-protein coding RNA 520
Location	14q22.3
Locus type	RNA, long non-coding
Status	Approved
Aliases	LENT, LASSIE, LEENE, LncRNA00520
Ensembl gene	ENSG00000258791
Ensembl biotype	lncRNA
OMIM	620533
Entrez	645687
RNAcentral	URS000075CB1B — lncRNA, 2092 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 12 — 12 lncRNA

ENST00000554186, ENST00000554196, ENST00000554221, ENST00000556417, ENST00000560267, ENST00000560336, ENST00000647781, ENST00000648365, ENST00000649691, ENST00000649892, ENST00000650020, ENST00000650527

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000554186 — 3 exons

Exon	Start	End
ENSE00002443521	55792727	55793456
ENSE00002504872	55794284	55794345
ENSE00002514609	55796603	55796639

Expression profiles

Bgee: expression breadth ubiquitous, 155 present calls, max score 91.86.

FANTOM5 (CAGE): breadth broad, TPM avg 1.8746 / max 126.7714, expressed in 440 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
143375	1.8746	440

Top tissues by expression

210 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
amniotic fluid	UBERON:0000173	91.86	gold quality
superficial temporal artery	UBERON:0001614	88.09	silver quality
mucosa of paranasal sinus	UBERON:0005030	84.15	silver quality
gingival epithelium	UBERON:0001949	83.48	silver quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	82.03	silver quality
lower lobe of lung	UBERON:0008949	77.81	gold quality
gingiva	UBERON:0001828	77.77	silver quality
skeletal muscle tissue of rectus abdominis	UBERON:0004511	76.10	gold quality
cardia of stomach	UBERON:0001162	75.84	silver quality
upper leg skin	UBERON:0004262	75.70	gold quality
esophagus squamous epithelium	UBERON:0006920	75.53	silver quality
nasal cavity epithelium	UBERON:0005384	74.31	gold quality
pericardium	UBERON:0002407	74.10	gold quality
skeletal muscle tissue of biceps brachii	UBERON:0004502	73.26	gold quality
skin of hip	UBERON:0001554	73.09	gold quality
mucosa of stomach	UBERON:0001199	71.95	gold quality
superior surface of tongue	UBERON:0007371	71.75	silver quality
colonic epithelium	UBERON:0000397	71.31	gold quality
pons	UBERON:0000988	71.04	silver quality
secondary oocyte	CL:0000655	70.35	silver quality
trachea	UBERON:0003126	70.15	gold quality
epithelium of nasopharynx	UBERON:0001951	70.11	gold quality
muscle tissue	UBERON:0002385	69.09	gold quality
cerebellar vermis	UBERON:0004720	69.07	gold quality
myocardium	UBERON:0002349	68.96	gold quality
mammary duct	UBERON:0001765	68.76	gold quality
tonsil	UBERON:0002372	68.23	silver quality
corpus epididymis	UBERON:0004359	67.15	gold quality
vena cava	UBERON:0004087	67.14	gold quality
ganglionic eminence	UBERON:0004023	66.80	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	4.22

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 13)

• Expression of LINC00520 is regulated by oncogenic Src, PIK3CA and STAT3, and may contribute to the molecular etiology of breast cancer. (PMID:27626181)
• Long non-coding RNA LEENE (gene name LINC00520, aka C14orf34) enhances endothelial nitric oxide synthase (eNOS) transcription and endothelial cells (ECs) function. (PMID:29348663)
• Overexpression of LINC00520 contributes to the aggravation of Acute kidney injury by targeting miR-27b-3p/ OSMR. (PMID:30684280)
• LINC00520-targeted EGFR inhibition might result in the inactivation of the PI3K/Akt pathway, thus inhibiting cutaneous squamous cell carcinoma (cSCC) development. (PMID:30707166)
• LINC00520 expression is up-regulated in nasopharyngeal carcinoma (NPC) tissues and cells, and its overexpression is associated with poor prognosis. Its knockdown showed tumor-suppressive roles via repressing NPC cell proliferation and tumor growth. LINC00520 mediates its function through functioning as a ceRNA for miR-26b, releasing the miR-26b inhibitory role for its target gene USP39. (PMID:30898716)
• Characterization of lncRNA LINC00520 and functional polymorphisms associated with breast cancer susceptibility in Chinese Han population. (PMID:31997582)
• Long non-coding RNA LINC00520 promotes the proliferation and metastasis of malignant melanoma by inducing the miR-125b-5p/EIF5A2 axis. (PMID:32466797)
• SP1-induced overexpression of LINC00520 facilitates non-small cell lung cancer progression through miR-577/CCNE2 pathway and predicts poor prognosis. (PMID:33728585)
• LINC00520 up-regulates SOX5 to promote cell proliferation and invasion by miR-4516 in human hepatocellular carcinoma. (PMID:35089659)
• LINC00520: A Potential Diagnostic and Prognostic Biomarker in Cancer. (PMID:35309319)
• Long noncoding RNA LEENE promotes angiogenesis and ischemic recovery in diabetes models. (PMID:36512424)
• Endothelial cells LEENE on noncoding RNAs in diabetic vasculopathy. (PMID:36719373)
• LINC00520 promotes colorectal cancer progression through miRNA-195-3p / NAT2 axis. (PMID:38836661)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.