LINC00523

Summary

LINC00523 (long intergenic non-protein coding RNA 523, HGNC:20117) is a long non-coding RNA gene on chromosome 14q32.2.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:20117
Approved symbol	LINC00523
Name	long intergenic non-protein coding RNA 523
Location	14q32.2
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000196273
Ensembl biotype	lncRNA
Entrez	283601
RNAcentral	URS0000114413 — lncRNA, 1627 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 13 — 13 lncRNA

ENST00000360899, ENST00000553367, ENST00000553623, ENST00000554195, ENST00000556308, ENST00000556697, ENST00000655680, ENST00000656919, ENST00000663191, ENST00000671653, ENST00000824501, ENST00000824502, ENST00000824503

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000360899 — 2 exons

Exon	Start	End
ENSE00004233777	100657245	100657710
ENSE00004233781	100671561	100672777

Expression profiles

Bgee: expression breadth broad, 64 present calls, max score 73.34.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.0441 / max 22.3766, expressed in 15 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
141476	0.0309	14
141477	0.0132	2

Top tissues by expression

185 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
nucleus accumbens	UBERON:0001882	73.34	gold quality
sperm	CL:0000019	72.37	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	72.27	gold quality
coronary artery	UBERON:0001621	72.21	gold quality
vena cava	UBERON:0004087	71.87	gold quality
lateral globus pallidus	UBERON:0002476	71.49	gold quality
oocyte	CL:0000023	70.12	gold quality
substantia nigra pars reticulata	UBERON:0001966	69.99	gold quality
subthalamic nucleus	UBERON:0001906	69.94	gold quality
saphenous vein	UBERON:0007318	69.64	gold quality
dorsal plus ventral thalamus	UBERON:0001897	69.54	gold quality
caecum	UBERON:0001153	69.45	gold quality
nipple	UBERON:0002030	69.45	gold quality
cardia of stomach	UBERON:0001162	69.40	gold quality
synovial joint	UBERON:0002217	69.39	gold quality
thymus	UBERON:0002370	69.29	gold quality
corpus callosum	UBERON:0002336	69.17	gold quality
cerebellar hemisphere	UBERON:0002245	69.14	gold quality
substantia nigra pars compacta	UBERON:0001965	69.10	gold quality
layer of synovial tissue	UBERON:0007616	69.10	gold quality
inferior vagus X ganglion	UBERON:0005363	69.06	gold quality
secondary oocyte	CL:0000655	69.05	gold quality
ventral tegmental area	UBERON:0002691	69.03	gold quality
cerebellar vermis	UBERON:0004720	68.98	gold quality
lateral nuclear group of thalamus	UBERON:0002736	68.95	gold quality
superior surface of tongue	UBERON:0007371	68.93	gold quality
cardiac atrium	UBERON:0002081	68.91	gold quality
pericardium	UBERON:0002407	68.85	gold quality
body of tongue	UBERON:0011876	68.85	gold quality
pharyngeal mucosa	UBERON:0000355	68.82	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.46

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Findings indicated that decreased expression of lncRNAs LINC00523 in T2DM patients was associated with T2DM susceptibility in an Iranian population. LINC00523 could be considered an effective diagnostic biomarker for T2DM. (PMID:30043104)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.