LINC00525

Summary

LINC00525 (long intergenic non-protein coding RNA 525, HGNC:40290) is a long non-coding RNA gene on chromosome 7p12.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:40290
Approved symbol	LINC00525
Name	long intergenic non-protein coding RNA 525
Location	7p12.3
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000146666
Ensembl biotype	lncRNA
Entrez	84847
RNAcentral	URS000075A113 — lncRNA, 1204 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 lncRNA

ENST00000412730

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000412730 — 3 exons

Exon	Start	End
ENSE00001646788	47763373	47763578
ENSE00001730806	47761476	47761513
ENSE00001739639	47765829	47766772

Expression profiles

Bgee: expression breadth ubiquitous, 108 present calls, max score 85.69.

Top tissues by expression

202 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	85.69	gold quality
bone marrow cell	CL:0002092	71.43	silver quality
ganglionic eminence	UBERON:0004023	62.07	gold quality
hindlimb stylopod muscle	UBERON:0004252	59.39	gold quality
apex of heart	UBERON:0002098	58.92	gold quality
tonsil	UBERON:0002372	56.19	gold quality
right lobe of liver	UBERON:0001114	54.12	gold quality
calcaneal tendon	UBERON:0003701	53.94	silver quality
lymph node	UBERON:0000029	53.60	gold quality
islet of Langerhans	UBERON:0000006	52.76	gold quality
heart left ventricle	UBERON:0002084	52.64	gold quality
vermiform appendix	UBERON:0001154	52.31	gold quality
gall bladder	UBERON:0002110	52.24	gold quality
cardiac ventricle	UBERON:0002082	52.13	gold quality
pancreas	UBERON:0001264	51.02	gold quality
muscle of leg	UBERON:0001383	49.87	silver quality
monocyte	CL:0000576	49.84	silver quality
heart	UBERON:0000948	49.62	gold quality
caecum	UBERON:0001153	49.57	gold quality
spleen	UBERON:0002106	49.36	gold quality
skin of hip	UBERON:0001554	49.01	silver quality
rectum	UBERON:0001052	47.87	gold quality
gastrocnemius	UBERON:0001388	47.53	silver quality
liver	UBERON:0002107	47.50	gold quality
tendon	UBERON:0000043	47.34	silver quality
right adrenal gland cortex	UBERON:0035827	46.96	gold quality
right adrenal gland	UBERON:0001233	46.28	gold quality
urinary bladder	UBERON:0001255	45.94	gold quality
cerebellar cortex	UBERON:0002129	45.81	silver quality
olfactory segment of nasal mucosa	UBERON:0005386	45.80	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.26

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 4)

• Long non-coding RNA LINC00525 interacts with miR-31-5p and miR-125a-5p to act as an oncogenic molecule in spinal chordoma. (PMID:33370717)
• LncRNA LINC00525 suppresses p21 expression via mRNA decay and triplex-mediated changes in chromatin structure in lung adenocarcinoma. (PMID:34105888)
• LncRNA LINC00525 activates HIF-1alpha through miR-338-3p / UBE2Q1 / beta-catenin axis to regulate the Warburg effect in colorectal cancer. (PMID:35156520)
• LINC00525 promotes tumour growth and epithelial-mesenchymal transition as an oncogene in oral squamous cell carcinoma. (PMID:37183989)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.