LINC00528

Summary

LINC00528 (long intergenic non-protein coding RNA 528, HGNC:26875) is a long non-coding RNA gene on chromosome 22q11.21.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:26875
Approved symbol	LINC00528
Name	long intergenic non-protein coding RNA 528
Location	22q11.21
Locus type	RNA, long non-coding
Status	Approved
Aliases	FLJ40542
Ensembl gene	ENSG00000269220
Ensembl biotype	lncRNA
Entrez	200298
RNAcentral	URS000075E032 — lncRNA, 2192 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 3 — 3 lncRNA

ENST00000600723, ENST00000840516, ENST00000840517

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000600723 — 1 exons

Exon	Start	End
ENSE00004263951	17777317	17779481

Expression profiles

Bgee: expression breadth ubiquitous, 140 present calls, max score 79.71.

FANTOM5 (CAGE): breadth broad, TPM avg 3.2141 / max 617.0602, expressed in 338 samples.

FANTOM5 promoters (4 alternative TSS)

Promoter ID	TPM avg	Samples expressed
190996	1.5112	301
190997	1.0832	114
190998	0.4373	73
190999	0.1825	49

Top tissues by expression

233 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
bone marrow cell	CL:0002092	79.71	gold quality
blood	UBERON:0000178	79.29	gold quality
monocyte	CL:0000576	76.92	gold quality
leukocyte	CL:0000738	76.71	gold quality
granulocyte	CL:0000094	75.87	gold quality
spleen	UBERON:0002106	75.25	gold quality
lymph node	UBERON:0000029	72.32	gold quality
vermiform appendix	UBERON:0001154	70.34	gold quality
bone marrow	UBERON:0002371	69.98	gold quality
caecum	UBERON:0001153	63.84	gold quality
tonsil	UBERON:0002372	61.70	gold quality
small intestine Peyer’s patch	UBERON:0003454	61.50	gold quality
thymus	UBERON:0002370	61.22	silver quality
cortical plate	UBERON:0005343	60.97	gold quality
small intestine	UBERON:0002108	59.59	gold quality
ventricular zone	UBERON:0003053	58.51	silver quality
buccal mucosa cell	CL:0002336	58.36	gold quality
trabecular bone tissue	UBERON:0002483	56.64	gold quality
right lobe of liver	UBERON:0001114	56.34	gold quality
nasal cavity mucosa	UBERON:0001826	56.34	gold quality
cerebellar vermis	UBERON:0004720	55.98	gold quality
rectum	UBERON:0001052	55.96	gold quality
mucosa of transverse colon	UBERON:0004991	55.78	gold quality
gall bladder	UBERON:0002110	55.71	gold quality
palpebral conjunctiva	UBERON:0001812	55.63	gold quality
right lung	UBERON:0002167	55.17	gold quality
upper lobe of left lung	UBERON:0008952	54.54	gold quality
parotid gland	UBERON:0001831	54.36	gold quality
upper lobe of lung	UBERON:0008948	54.25	gold quality
transverse colon	UBERON:0001157	52.40	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.57

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• LINC00528 regulates myocardial infarction by targeting the miR-143-3p/COX-2 axis. (PMID:31833800)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.