LINC00536

Summary

LINC00536 (long intergenic non-protein coding RNA 536, HGNC:43645) is a long non-coding RNA gene on chromosome 8q23.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:43645
Approved symbol	LINC00536
Name	long intergenic non-protein coding RNA 536
Location	8q23.3
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000249917
Ensembl biotype	lncRNA
Entrez	100859921
RNAcentral	URS0000097924 — lncRNA, 2692 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 10 — 10 lncRNA

ENST00000505156, ENST00000664052, ENST00000835235, ENST00000835236, ENST00000835237, ENST00000835238, ENST00000835239, ENST00000835240, ENST00000835241, ENST00000835242

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000505156 — 14 exons

Exon	Start	End
ENSE00002026821	115976070	115976135
ENSE00002027873	116259492	116260031
ENSE00002032358	115954929	115955005
ENSE00002039609	115969684	115969777
ENSE00002048673	116273481	116273712
ENSE00002058590	115951463	115951570
ENSE00002060419	115977243	115977436
ENSE00002063497	116324830	116325059
ENSE00002072094	116130198	116130280
ENSE00002077333	116260347	116260677
ENSE00002078589	116125372	116125418
ENSE00002079147	115963793	115964158
ENSE00002083694	116119689	116119783
ENSE00002087645	115950511	115950739

Expression profiles

Bgee: expression breadth broad, 42 present calls, max score 77.33.

Top tissues by expression

166 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	77.33	silver quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	64.77	gold quality
sural nerve	UBERON:0015488	63.33	silver quality
lower esophagus mucosa	UBERON:0035834	54.72	gold quality
islet of Langerhans	UBERON:0000006	54.06	gold quality
monocyte	CL:0000576	53.57	silver quality
pancreas	UBERON:0001264	52.71	gold quality
minor salivary gland	UBERON:0001830	52.35	gold quality
calcaneal tendon	UBERON:0003701	50.56	silver quality
lower esophagus muscularis layer	UBERON:0035833	50.38	gold quality
buccal mucosa cell	CL:0002336	50.26	gold quality
prefrontal cortex	UBERON:0000451	49.23	silver quality
anterior cingulate cortex	UBERON:0009835	48.07	silver quality
esophagus	UBERON:0001043	48.03	gold quality
esophagus mucosa	UBERON:0002469	47.90	gold quality
lymph node	UBERON:0000029	47.59	silver quality
mouth mucosa	UBERON:0003729	47.21	gold quality
saliva-secreting gland	UBERON:0001044	46.82	gold quality
gall bladder	UBERON:0002110	45.91	silver quality
upper lobe of lung	UBERON:0008948	43.43	silver quality
skeletal muscle tissue of rectus abdominis	UBERON:0004511	43.37	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	43.27	gold quality
lower lobe of lung	UBERON:0008949	43.13	silver quality
secondary oocyte	CL:0000655	42.57	gold quality
Brodmann (1909) area 9	UBERON:0013540	42.28	silver quality
blood	UBERON:0000178	42.08	gold quality
skin of abdomen	UBERON:0001416	42.05	gold quality
vagina	UBERON:0000996	41.80	gold quality
adult mammalian kidney	UBERON:0000082	41.50	gold quality
vastus lateralis	UBERON:0001379	41.41	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	4.91

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 3)

• HIgh LINC00536 expression is associated with tumor progression and poor prognosis in bladder cancer. (PMID:30851243)
• LINC00536 promotes hepatocellular carcinoma progression via the miR-203b-5p/VEGFA axis. (PMID:34881629)
• LINC00536 Promotes Breast Cancer Progression by Regulating ROCK1 via Sponging of miR-214-5p. (PMID:36513954)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.