LINC00537

Summary

LINC00537 (long intergenic non-protein coding RNA 537, HGNC:43654) is a long non-coding RNA gene on chromosome 9q13.

Predicted to be a structural constituent of ribosome. Predicted to be located in ribosome.

Source: NCBI Gene 203274 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 1 total

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:43654
Approved symbol	LINC00537
Name	long intergenic non-protein coding RNA 537
Location	9q13
Locus type	RNA, long non-coding
Status	Approved
Entrez	203274
RNAcentral	URS0000BC44FE — lncRNA, 4288 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 0

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

None — 0 exons

Expression profiles

Top tissues by expression

0 total, by Bgee expression score (0-100, higher = more expressed):

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Protein identifiers

Canonical reviewed UniProt: None (reviewed: )

All UniProt accessions (0):

RefSeq proteins (0): (*=MANE)

Domains & families (InterPro)

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 0 (showing top):

GO Biological Process (0):

GO Molecular Function (0):

GO Cellular Component (0):

Protein interactions and networks

STRING

0 interactions, top by confidence (×1000):

IntAct

0 interactions, top by confidence:

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

1 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	0
Likely benign	0
Benign	1

Top pathogenic / likely-pathogenic (0)

SpliceAI

0 predictions. Top by Δscore:

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1001080770 (9:63812819 C>A,G,T), RS1001177253 (9:63811108 C>T), RS1001711828 (9:63811345 T>C), RS1002309960 (9:63813420 C>A,T), RS1002579041 (9:63813221 T>C), RS1002641871 (9:63814000 G>T), RS1003181297 (9:63815559 A>T), RS1003684168 (9:63815730 C>A,T), RS1004021366 (9:63813447 C>G,T), RS1004112982 (9:63814179 TC>T), RS1008261650 (9:63816983 T>C,G), RS1008503089 (9:63812483 C>G), RS1008647956 (9:63811781 T>C,G), RS1009266183 (9:63811162 T>C), RS1009591463 (9:63813093 G>A,C,T)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 0 entries

CTD chemical–gene interactions

7 total (human), top 7 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	affects cotreatment, increases expression	5
lead acetate	affects cotreatment, increases expression	1
zinc protoporphyrin	affects cotreatment, increases expression	1
entinostat	increases expression	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, increases expression	1
dorsomorphin	affects cotreatment, increases expression	1
Smoke	decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.