LINC00538

Summary

LINC00538 (long intergenic non-protein coding RNA 538, HGNC:43655) is a long non-coding RNA gene on chromosome 1q32.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:43655
Approved symbol	LINC00538
Name	long intergenic non-protein coding RNA 538
Location	1q32.3
Locus type	RNA, long non-coding
Status	Approved
Aliases	Yiya, PROX1UT
Ensembl gene	ENSG00000281664
Ensembl biotype	lncRNA
OMIM	614635
Entrez	100861504
RNAcentral	URS00004ECF3F — lncRNA, 1906 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 lncRNA

ENST00000626109

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000626109 — 1 exons

Exon	Start	End
ENSE00003761091	213924749	213926654

Expression profiles

Bgee: expression breadth broad, 24 present calls, max score 57.47.

Top tissues by expression

24 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
liver	UBERON:0002107	57.47	gold quality
ovary	UBERON:0000992	53.96	silver quality
prefrontal cortex	UBERON:0000451	49.96	silver quality
islet of Langerhans	UBERON:0000006	48.14	silver quality
multicellular organism	UBERON:0000468	47.64	silver quality
heart	UBERON:0000948	47.10	silver quality
thyroid gland	UBERON:0002046	46.87	silver quality
adipose tissue	UBERON:0001013	46.58	silver quality
right lobe of liver	UBERON:0001114	45.66	silver quality
Brodmann (1909) area 9	UBERON:0013540	44.83	silver quality
hypothalamus	UBERON:0001898	43.70	gold quality
amygdala	UBERON:0001876	43.57	silver quality
cerebellar hemisphere	UBERON:0002245	42.78	silver quality
dorsolateral prefrontal cortex	UBERON:0009834	42.35	silver quality
body of pancreas	UBERON:0001150	41.92	silver quality
adrenal gland	UBERON:0002369	41.63	silver quality
right hemisphere of cerebellum	UBERON:0014890	41.36	silver quality
right frontal lobe	UBERON:0002810	40.19	silver quality
Ammon’s horn	UBERON:0001954	39.52	silver quality
caudate nucleus	UBERON:0001873	38.89	silver quality
substantia nigra	UBERON:0002038	38.83	silver quality
putamen	UBERON:0001874	37.43	silver quality
left adrenal gland cortex	UBERON:0035825	37.42	silver quality
C1 segment of cervical spinal cord	UBERON:0006469	36.38	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.98

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• GAS5 and Yiya have roles in liver metastases in patients with early stage colorectal cancer and may be useful tumor markers (PMID:27391432)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.