LINC00574

Summary

LINC00574 (long intergenic non-protein coding RNA 574, HGNC:21598) is a long non-coding RNA gene on chromosome 6q27.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:21598
Approved symbol	LINC00574
Name	long intergenic non-protein coding RNA 574
Location	6q27
Locus type	RNA, long non-coding
Status	Approved
Aliases	FLJ13162, dJ182D15.1, CRALA
Ensembl gene	ENSG00000231690
Ensembl biotype	lncRNA
Entrez	80069
RNAcentral	URS000075C848 — lncRNA, 2566 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 23 — 23 lncRNA

ENST00000420557, ENST00000686336, ENST00000689618, ENST00000690995, ENST00000768725, ENST00000768726, ENST00000768727, ENST00000768728, ENST00000768729, ENST00000768730, ENST00000768731, ENST00000768732, ENST00000768733, ENST00000768734, ENST00000768735, ENST00000768736, ENST00000768737, ENST00000768738, ENST00000768739, ENST00000768740, ENST00000768741, ENST00000768742, ENST00000768743

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000420557 — 3 exons

Exon	Start	End
ENSE00001678751	169795184	169795362
ENSE00004129288	169790044	169790416
ENSE00004129290	169800831	169802893

Expression profiles

Bgee: expression breadth ubiquitous, 109 present calls, max score 65.83.

FANTOM5 (CAGE): breadth broad, TPM avg 0.5339 / max 25.0981, expressed in 264 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
71278	0.3582	147
71279	0.1757	76

Top tissues by expression

109 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
liver	UBERON:0002107	65.83	gold quality
right lobe of liver	UBERON:0001114	65.31	gold quality
cortical plate	UBERON:0005343	63.01	gold quality
ganglionic eminence	UBERON:0004023	61.93	gold quality
ventricular zone	UBERON:0003053	61.27	gold quality
duodenum	UBERON:0002114	58.57	gold quality
prefrontal cortex	UBERON:0000451	56.90	gold quality
stromal cell of endometrium	CL:0002255	54.69	silver quality
primary visual cortex	UBERON:0002436	54.46	gold quality
frontal cortex	UBERON:0001870	53.57	gold quality
nucleus accumbens	UBERON:0001882	52.63	gold quality
islet of Langerhans	UBERON:0000006	52.51	gold quality
cerebral cortex	UBERON:0000956	51.40	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	50.91	gold quality
anterior cingulate cortex	UBERON:0009835	50.76	gold quality
pancreas	UBERON:0001264	50.67	gold quality
superior frontal gyrus	UBERON:0002661	50.40	gold quality
hypothalamus	UBERON:0001898	50.33	gold quality
lymph node	UBERON:0000029	50.04	silver quality
Brodmann (1909) area 9	UBERON:0013540	49.86	gold quality
putamen	UBERON:0001874	49.79	gold quality
brain	UBERON:0000955	49.29	gold quality
right frontal lobe	UBERON:0002810	49.08	gold quality
caudate nucleus	UBERON:0001873	48.76	gold quality
smooth muscle tissue	UBERON:0001135	48.72	gold quality
ovary	UBERON:0000992	47.50	gold quality
adult mammalian kidney	UBERON:0000082	47.26	gold quality
blood	UBERON:0000178	46.95	silver quality
left ovary	UBERON:0002119	46.90	gold quality
right ovary	UBERON:0002118	46.81	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.34

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 3)

• Results identified LINC00574 as a chemoresistance-associated long non-coding RNA (CRALA). In breast neoplasm specimens, non-responding tumors to chemotherapy had fourfold higher CRALA expression than responding tumors, and is associated with poor prognosis. Silencing of CRALA in chemoresistant breast cancer cells resensitizes the cells to chemotherapy in vitro. (PMID:28834648)
• Coordinated Regulation of UGT2B15 Expression by Long Noncoding RNA LINC00574 and hsa-miR-129-5p in HepaRG Cells. (PMID:32086297)
• Study of Linc00574 Regulatory Effect on the TCTE3 Expression in Sperm Motility. (PMID:32749594)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.