LINC00578

Summary

LINC00578 (long intergenic non-protein coding RNA 578, HGNC:43807) is a long non-coding RNA gene on chromosome 3q26.32.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:43807
Approved symbol	LINC00578
Name	long intergenic non-protein coding RNA 578
Location	3q26.32
Locus type	RNA, long non-coding
Status	Approved
Aliases	AC026355.2
Ensembl gene	ENSG00000228221
Ensembl biotype	lncRNA
Entrez	100505566
RNAcentral	URS000075B315 — lncRNA, 1222 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 51 — 51 lncRNA

ENST00000423466, ENST00000439009, ENST00000442937, ENST00000445673, ENST00000446548, ENST00000656037, ENST00000657906, ENST00000660801, ENST00000661409, ENST00000661450, ENST00000665837, ENST00000668730, ENST00000671331, ENST00000716286, ENST00000850223, ENST00000850224, ENST00000850225, ENST00000850226, ENST00000850227, ENST00000850228, ENST00000850229, ENST00000850230, ENST00000850231, ENST00000850232, ENST00000850233, ENST00000850234, ENST00000850235, ENST00000850236, ENST00000850237, ENST00000850238, ENST00000850239, ENST00000850240, ENST00000850241, ENST00000850242, ENST00000850243, ENST00000850244, ENST00000850245, ENST00000850246, ENST00000850247, ENST00000850248, ENST00000850249, ENST00000850250, ENST00000850251, ENST00000850252, ENST00000850253, ENST00000850254, ENST00000850255, ENST00000850256, ENST00000850257, ENST00000850258, ENST00000850259

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000423466 — 4 exons

Exon	Start	End
ENSE00001718454	177691129	177691250
ENSE00001761947	177687402	177687588
ENSE00004029393	177683627	177683833
ENSE00004477437	177684944	177685014

Expression profiles

Bgee: expression breadth ubiquitous, 132 present calls, max score 86.05.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 1.1954 / max 128.8566, expressed in 151 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
39888	0.9816	141
39887	0.1295	65
39886	0.0844	34

Top tissues by expression

132 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
lower esophagus muscularis layer	UBERON:0035833	86.05	gold quality
lower esophagus	UBERON:0013473	86.01	gold quality
smooth muscle tissue	UBERON:0001135	85.24	gold quality
muscle layer of sigmoid colon	UBERON:0035805	84.29	gold quality
colonic epithelium	UBERON:0000397	82.45	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	81.15	gold quality
muscle tissue	UBERON:0002385	78.98	gold quality
myometrium	UBERON:0001296	78.37	gold quality
prostate gland	UBERON:0002367	78.31	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	77.83	gold quality
mucosa of stomach	UBERON:0001199	77.52	gold quality
esophagus	UBERON:0001043	77.51	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	77.24	gold quality
colon	UBERON:0001155	75.82	gold quality
intestine	UBERON:0000160	73.81	gold quality
sural nerve	UBERON:0015488	73.62	gold quality
lower esophagus mucosa	UBERON:0035834	73.45	gold quality
body of uterus	UBERON:0009853	72.92	gold quality
rectum	UBERON:0001052	71.98	gold quality
gall bladder	UBERON:0002110	71.00	gold quality
left uterine tube	UBERON:0001303	70.99	gold quality
fundus of stomach	UBERON:0001160	70.42	gold quality
vermiform appendix	UBERON:0001154	69.90	gold quality
stromal cell of endometrium	CL:0002255	69.76	gold quality
esophagus mucosa	UBERON:0002469	69.67	gold quality
small intestine	UBERON:0002108	69.47	gold quality
transverse colon	UBERON:0001157	68.84	gold quality
small intestine Peyer’s patch	UBERON:0003454	68.76	gold quality
upper lobe of left lung	UBERON:0008952	67.13	gold quality
stomach	UBERON:0000945	66.60	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	3.05

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.