LINC00589

Summary

LINC00589 (long intergenic non-protein coding RNA 589, HGNC:32299) is a long non-coding RNA gene on chromosome 8p12.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32299
Approved symbol	LINC00589
Name	long intergenic non-protein coding RNA 589
Location	8p12
Locus type	RNA, long non-coding
Status	Approved
Aliases	TSLNC8
Ensembl gene	ENSG00000251191
Ensembl biotype	lncRNA
Entrez	619351
RNAcentral	URS0000CCE0F1 — lncRNA, 1413 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 24 — 24 lncRNA

ENST00000506121, ENST00000518623, ENST00000662593, ENST00000770775, ENST00000770776, ENST00000770777, ENST00000770778, ENST00000770779, ENST00000770780, ENST00000770781, ENST00000770782, ENST00000770783, ENST00000770784, ENST00000770785, ENST00000770786, ENST00000770787, ENST00000770788, ENST00000770789, ENST00000770790, ENST00000770791, ENST00000770792, ENST00000770793, ENST00000770794, ENST00000770795

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000506121 — 4 exons

Exon	Start	End
ENSE00002022075	29726156	29726423
ENSE00002053478	29721254	29722151
ENSE00002079921	29724877	29725019
ENSE00002126137	29748015	29748109

Expression profiles

Bgee: expression breadth broad, 83 present calls, max score 81.15.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.1914 / max 46.8148, expressed in 65 samples.

FANTOM5 promoters (4 alternative TSS)

Promoter ID	TPM avg	Samples expressed
92576	0.1062	39
92578	0.0416	13
92575	0.0387	10
92577	0.0049	3

Top tissues by expression

193 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	81.15	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	65.28	gold quality
right uterine tube	UBERON:0001302	54.29	gold quality
islet of Langerhans	UBERON:0000006	53.26	gold quality
muscle of leg	UBERON:0001383	52.93	gold quality
gastrocnemius	UBERON:0001388	52.77	gold quality
nasal cavity mucosa	UBERON:0001826	52.52	gold quality
gall bladder	UBERON:0002110	52.17	gold quality
hindlimb stylopod muscle	UBERON:0004252	51.88	gold quality
pancreas	UBERON:0001264	51.65	gold quality
rectum	UBERON:0001052	51.62	gold quality
monocyte	CL:0000576	49.97	silver quality
lymph node	UBERON:0000029	49.05	gold quality
body of stomach	UBERON:0001161	47.60	gold quality
prefrontal cortex	UBERON:0000451	47.14	silver quality
fallopian tube	UBERON:0003889	47.00	gold quality
stomach	UBERON:0000945	46.97	gold quality
tendon of biceps brachii	UBERON:0008188	46.46	gold quality
vagina	UBERON:0000996	45.59	gold quality
vermiform appendix	UBERON:0001154	45.57	silver quality
mucosa of transverse colon	UBERON:0004991	45.56	gold quality
minor salivary gland	UBERON:0001830	45.35	gold quality
cortex of kidney	UBERON:0001225	45.02	silver quality
body of pancreas	UBERON:0001150	44.97	silver quality
left adrenal gland cortex	UBERON:0035825	44.87	gold quality
tonsil	UBERON:0002372	44.83	gold quality
saliva-secreting gland	UBERON:0001044	44.65	silver quality
small intestine	UBERON:0002108	44.34	gold quality
mouth mucosa	UBERON:0003729	44.29	silver quality
duodenum	UBERON:0002114	44.13	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	3.93

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 4)

• the present study revealed the importance of a novel lncRNA, TSLNC8, in human glioma. TSLNC8 was demonstrated to inhibit cell proliferation and metastasis, and promote cell apoptosis in glioma cells. (PMID:30387847)
• TSLNC8 remarkably inhibited the proliferation and migration and accelerated apoptosis of lung cancer cells by targeting the IL-6/STAT3/HIF-1alpha signaling pathway. (PMID:31601776)
• Long noncoding RNA TSLNC8 enhances pancreatic cancer aggressiveness by regulating CTNNB1 expression via association with HuR. (PMID:32951177)
• Downregulation of lncRNA TSLNC8 promotes melanoma resistance to BRAF inhibitor PLX4720 through binding with PP1alpha to re-activate MAPK signaling. (PMID:33389075)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.