LINC00597

Summary

LINC00597 (long intergenic non-protein coding RNA 597, HGNC:1193) is a long non-coding RNA gene on chromosome 15q23-q24.

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:1193
Approved symbol	LINC00597
Name	long intergenic non-protein coding RNA 597
Location	15q23-q24
Locus type	RNA, long non-coding
Status	Approved
Entrez	81698
RNAcentral	URS000075ED0F — lncRNA, 1512 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 0

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

None — 0 exons

Expression profiles

Top tissues by expression

0 total, by Bgee expression score (0-100, higher = more expressed):

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Protein identifiers

Putative uncharacterized protein encoded by LINC00597 — Q9H2U6 (reviewed: Q9H2U6)

All UniProt accessions (0):

UniProt curated annotations — full annotation on UniProt →

Tissue specificity. Expressed in heart.

RefSeq proteins (0): (*=MANE)

Domains & families (InterPro)

UniProt features (1 total): chain 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9H2U6-F1	44.22	0.00

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 0 (showing top):

GO Biological Process (0):

GO Molecular Function (0):

GO Cellular Component (0):

Protein interactions and networks

STRING

0 interactions, top by confidence (×1000):

IntAct

0 interactions, top by confidence:

ESM2 similar proteins: A0RBM3, A4QKE9, A4QL63, A4QLF0, A7GMV1, A9CB95, B1AMM8, B7HHG6, B7INA4, B7JFZ6, C1EMQ8, C3L9P6, C4QGM3, O36379, P02660, P05899, P06508, P06944, P0C074, P0CV35, P19122, P20402, P21100, P35977, P37589, P44264, P49409, P53231, P60540, Q06GT5, Q07032, Q07989, Q07VS5, Q08590, Q09FP9, Q0G9F8, Q0ZIV7, Q33BV4, Q55BF5, Q5I133

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

0 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	0
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

0 predictions. Top by Δscore:

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1000843552 (15:77225404 C>T), RS1000917162 (15:77225633 G>A,C), RS1001285435 (15:77226242 A>C), RS1002000741 (15:77223612 T>C), RS1002284945 (15:77224677 T>A,C), RS1002330158 (15:77223804 C>T), RS1002736504 (15:77225016 C>A), RS1003411018 (15:77225281 G>A), RS1003740042 (15:77223448 C>G), RS1003936358 (15:77223418 A>T), RS1004940312 (15:77224913 G>A), RS1005038575 (15:77225220 C>G), RS1005149257 (15:77226199 T>C), RS1005485781 (15:77225813 C>T), RS1005946313 (15:77226834 A>G)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

18 total (human), top 18 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	increases expression, affects cotreatment	4
bisphenol A	decreases expression, affects cotreatment	2
Phenylmercuric Acetate	affects cotreatment, increases expression	2
trichostatin A	increases expression	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, increases expression	1
dorsomorphin	increases expression, affects cotreatment	1
bisphenol S	affects cotreatment, decreases expression	1
Irinotecan	decreases expression	1
Vorinostat	increases expression	1
Acetaminophen	increases expression	1
Benzo(a)pyrene	affects methylation	1
Dexamethasone	affects cotreatment, decreases expression	1
Indomethacin	affects cotreatment, decreases expression	1
Silicon Dioxide	increases expression	1
1-Methyl-3-isobutylxanthine	affects cotreatment, decreases expression	1
Oxyquinoline	decreases expression	1
Cadmium Chloride	increases expression	1
Copper Sulfate	increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.