LINC00598

Summary

LINC00598 (long intergenic non-protein coding RNA 598, HGNC:42770) is a long non-coding RNA gene on chromosome 13q14.11.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:42770
Approved symbol	LINC00598
Name	long intergenic non-protein coding RNA 598
Location	13q14.11
Locus type	RNA, long non-coding
Status	Approved
Aliases	TTL, lncFOXO1
Ensembl gene	ENSG00000215483
Ensembl biotype	lncRNA
OMIM	619008
Entrez	646982
RNAcentral	URS00026A206E — lncRNA, 2086 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 40 — 40 lncRNA

ENST00000400430, ENST00000400431, ENST00000400432, ENST00000542632, ENST00000615137, ENST00000615947, ENST00000616706, ENST00000617777, ENST00000635966, ENST00000636192, ENST00000636621, ENST00000637124, ENST00000637438, ENST00000637523, ENST00000638084, ENST00000638163, ENST00000653296, ENST00000654662, ENST00000658497, ENST00000661694, ENST00000663730, ENST00000667216, ENST00000667316, ENST00000670910, ENST00000685572, ENST00000726926, ENST00000726927, ENST00000726928, ENST00000782811, ENST00000782813, ENST00000782814, ENST00000782815, ENST00000782816, ENST00000782817, ENST00000782818, ENST00000782819, ENST00000782820, ENST00000782821, ENST00000782822, ENST00000782823

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000400430 — 5 exons

Exon	Start	End
ENSE00001542840	40450994	40451203
ENSE00001542844	40469996	40470162
ENSE00001597742	40473994	40474095
ENSE00001683902	40480909	40481006
ENSE00003736127	40460282	40460406

Expression profiles

Bgee: expression breadth ubiquitous, 157 present calls, max score 95.86.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.2507 / max 127.1678, expressed in 29 samples.

FANTOM5 promoters (6 alternative TSS)

Promoter ID	TPM avg	Samples expressed
136905	0.0805	4
136907	0.0448	17
136904	0.0412	7
136906	0.0330	5
136903	0.0324	7
136902	0.0187	4

Top tissues by expression

244 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
buccal mucosa cell	CL:0002336	95.86	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	84.75	gold quality
colonic epithelium	UBERON:0000397	80.58	gold quality
sural nerve	UBERON:0015488	80.17	gold quality
omental fat pad	UBERON:0010414	79.73	gold quality
peritoneum	UBERON:0002358	79.62	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	79.34	gold quality
calcaneal tendon	UBERON:0003701	79.29	gold quality
adenohypophysis	UBERON:0002196	78.09	gold quality
adipose tissue of abdominal region	UBERON:0007808	77.60	gold quality
monocyte	CL:0000576	76.88	gold quality
right ovary	UBERON:0002118	76.66	gold quality
right lobe of liver	UBERON:0001114	75.67	gold quality
left ovary	UBERON:0002119	75.19	gold quality
tibial nerve	UBERON:0001323	74.70	gold quality
adrenal tissue	UBERON:0018303	74.53	gold quality
left testis	UBERON:0004533	74.08	gold quality
body of uterus	UBERON:0009853	74.08	gold quality
right testis	UBERON:0004534	73.99	gold quality
granulocyte	CL:0000094	73.83	gold quality
subcutaneous adipose tissue	UBERON:0002190	73.44	gold quality
pituitary gland	UBERON:0000007	73.33	gold quality
gastrocnemius	UBERON:0001388	72.72	gold quality
left uterine tube	UBERON:0001303	72.24	gold quality
testis	UBERON:0000473	72.09	gold quality
muscle of leg	UBERON:0001383	71.86	gold quality
islet of Langerhans	UBERON:0000006	71.27	gold quality
bone marrow cell	CL:0002092	71.25	silver quality
ovary	UBERON:0000992	70.79	gold quality
right uterine tube	UBERON:0001302	70.69	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	7.56

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• data indicate that linc00598 plays an important role in cell cycle regulation and proliferation through its ability to regulate the transcription of CCND2. (PMID:27572135)
• lncFOXO1 suppressed the growth of breast cancer by increasing FOXO1 transcription. Moreover, we found that lncFOXO1 associated with BRCA-1-associated protein 1 (BAP1) and regulates its binding and the level of mono-ubiquitinated H2A at K119 (ubH2AK119) at FOXO1 promoter (PMID:28339037)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.