LINC00607

Summary

LINC00607 (long intergenic non-protein coding RNA 607, HGNC:43944) is a long non-coding RNA gene on chromosome 2q35.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:43944
Approved symbol	LINC00607
Name	long intergenic non-protein coding RNA 607
Location	2q35
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000235770
Ensembl biotype	lncRNA
Entrez	646324
RNAcentral	URS0000126579 — lncRNA, 3690 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 49 — 49 lncRNA

ENST00000413563, ENST00000417922, ENST00000419922, ENST00000423530, ENST00000445174, ENST00000451392, ENST00000654368, ENST00000655043, ENST00000655131, ENST00000659768, ENST00000661231, ENST00000662624, ENST00000664275, ENST00000767126, ENST00000767127, ENST00000767128, ENST00000767129, ENST00000767130, ENST00000767131, ENST00000767132, ENST00000767133, ENST00000767134, ENST00000767135, ENST00000767136, ENST00000767137, ENST00000767138, ENST00000767139, ENST00000767140, ENST00000767141, ENST00000767142, ENST00000767143, ENST00000767144, ENST00000767145, ENST00000767146, ENST00000767147, ENST00000767148, ENST00000767149, ENST00000767150, ENST00000767151, ENST00000767152, ENST00000767153, ENST00000767154, ENST00000767155, ENST00000767156, ENST00000767157, ENST00000767158, ENST00000767159, ENST00000767160, ENST00000767161

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000413563 — 4 exons

Exon	Start	End
ENSE00001596901	215750243	215750417
ENSE00001672787	215743744	215743914
ENSE00001705094	215747304	215747394
ENSE00003872244	215827352	215827367

Expression profiles

Bgee: expression breadth ubiquitous, 153 present calls, max score 84.33.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.3314 / max 56.0813, expressed in 60 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
33753	0.3314	60

Top tissues by expression

237 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
buccal mucosa cell	CL:0002336	84.33	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	79.11	gold quality
right coronary artery	UBERON:0001625	70.01	gold quality
descending thoracic aorta	UBERON:0002345	68.88	gold quality
ventricular zone	UBERON:0003053	68.80	gold quality
sural nerve	UBERON:0015488	67.95	gold quality
thoracic aorta	UBERON:0001515	67.62	gold quality
ascending aorta	UBERON:0001496	67.40	gold quality
left coronary artery	UBERON:0001626	66.16	gold quality
bone marrow cell	CL:0002092	65.19	silver quality
aorta	UBERON:0000947	65.14	gold quality
coronary artery	UBERON:0001621	65.05	gold quality
tibial artery	UBERON:0007610	63.56	gold quality
popliteal artery	UBERON:0002250	63.55	gold quality
tendon of biceps brachii	UBERON:0008188	62.52	silver quality
stromal cell of endometrium	CL:0002255	61.98	gold quality
upper lobe of left lung	UBERON:0008952	61.24	gold quality
cortical plate	UBERON:0005343	60.89	gold quality
monocyte	CL:0000576	60.74	gold quality
tibial nerve	UBERON:0001323	60.43	gold quality
right lung	UBERON:0002167	60.09	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	59.56	gold quality
hindlimb stylopod muscle	UBERON:0004252	59.31	gold quality
upper lobe of lung	UBERON:0008948	59.15	gold quality
smooth muscle tissue	UBERON:0001135	59.13	gold quality
gall bladder	UBERON:0002110	58.50	gold quality
muscle layer of sigmoid colon	UBERON:0035805	57.88	gold quality
lower esophagus muscularis layer	UBERON:0035833	57.66	gold quality
lower esophagus	UBERON:0013473	57.62	gold quality
left uterine tube	UBERON:0001303	57.30	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	6.16

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• The endothelial-enriched lncRNA LINC00607 mediates angiogenic function. (PMID:36700983)
• MYC-activated LINC00607 promotes hepatocellular carcinoma progression by regulating the miR-584-3p/ROCK1 axis. (PMID:36740760)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.