LINC00612

Summary

LINC00612 (long intergenic non-protein coding RNA 612, HGNC:28621) is a long non-coding RNA gene on chromosome 12p13.31.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:28621
Approved symbol	LINC00612
Name	long intergenic non-protein coding RNA 612
Location	12p13.31
Locus type	RNA, long non-coding
Status	Approved
Aliases	MGC40170, FLJ41814
Ensembl gene	ENSG00000214851
Ensembl biotype	lncRNA
Entrez	253128
RNAcentral	URS000075B6CD — lncRNA, 2236 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 5 — 5 lncRNA

ENST00000538094, ENST00000675544, ENST00000839191, ENST00000839192, ENST00000839193

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000538094 — 3 exons

Exon	Start	End
ENSE00002239051	9055589	9055738
ENSE00004261164	9057620	9058876
ENSE00004261165	9064268	9065079

Expression profiles

Bgee: expression breadth ubiquitous, 128 present calls, max score 79.25.

Top tissues by expression

221 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	79.25	gold quality
bone marrow cell	CL:0002092	68.48	silver quality
ventricular zone	UBERON:0003053	58.41	silver quality
hindlimb stylopod muscle	UBERON:0004252	57.41	gold quality
calcaneal tendon	UBERON:0003701	57.13	gold quality
ganglionic eminence	UBERON:0004023	56.25	silver quality
olfactory segment of nasal mucosa	UBERON:0005386	56.18	gold quality
sural nerve	UBERON:0015488	53.22	silver quality
blood	UBERON:0000178	52.04	gold quality
leukocyte	CL:0000738	51.75	silver quality
monocyte	CL:0000576	50.66	silver quality
muscle of leg	UBERON:0001383	50.28	gold quality
islet of Langerhans	UBERON:0000006	50.23	gold quality
tendon	UBERON:0000043	50.21	gold quality
tibial nerve	UBERON:0001323	50.14	gold quality
popliteal artery	UBERON:0002250	50.11	gold quality
tibial artery	UBERON:0007610	50.11	gold quality
right lobe of thyroid gland	UBERON:0001119	49.71	gold quality
gastrocnemius	UBERON:0001388	49.46	gold quality
lymph node	UBERON:0000029	49.45	gold quality
right uterine tube	UBERON:0001302	49.41	gold quality
subcutaneous adipose tissue	UBERON:0002190	49.32	gold quality
skin of leg	UBERON:0001511	49.05	gold quality
body of uterus	UBERON:0009853	48.96	gold quality
left adrenal gland cortex	UBERON:0035825	48.71	gold quality
left ovary	UBERON:0002119	48.69	gold quality
heart left ventricle	UBERON:0002084	48.49	gold quality
mucosa of stomach	UBERON:0001199	48.32	gold quality
left adrenal gland	UBERON:0001234	48.15	gold quality
cardiac ventricle	UBERON:0002082	48.14	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.66

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 3)

• Results indicate that LINC00612 enhances the proliferation and invasion ability of bladder cancer (BC) cells by sponging miR-590 to upregulate PHF14 expression and promote BC cellular epithelial-mesenchymal transition, suggesting that LINC00612 may act as a potential biomarker for BC. (PMID:30940184)
• LINC00612 functions as a ceRNA for miR-214-5p to promote the proliferation and invasion of osteosarcoma in vitro and in vivo. (PMID:32311343)
• LincRNA00612 inhibits apoptosis and inflammation in LPS-induced BEAS-2B cells via enhancing interaction between p-STAT3 and A2M promoter. (PMID:36883061)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.