LINC00616

Summary

LINC00616 (long intergenic non-protein coding RNA 616, HGNC:44065) is a long non-coding RNA gene on chromosome 4q28.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:44065
Approved symbol	LINC00616
Name	long intergenic non-protein coding RNA 616
Location	4q28.3
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000248307
Ensembl biotype	lncRNA
Entrez	641365
RNAcentral	URS000007DDD8 — lncRNA, 2017 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 69 — 69 lncRNA

ENST00000503208, ENST00000505874, ENST00000512536, ENST00000513895, ENST00000514600, ENST00000653614, ENST00000653774, ENST00000654116, ENST00000654802, ENST00000655762, ENST00000656520, ENST00000656980, ENST00000658598, ENST00000658661, ENST00000659104, ENST00000659677, ENST00000660118, ENST00000660320, ENST00000660519, ENST00000660556, ENST00000661081, ENST00000661479, ENST00000661963, ENST00000662849, ENST00000663598, ENST00000663909, ENST00000664696, ENST00000665179, ENST00000665542, ENST00000665774, ENST00000666002, ENST00000666325, ENST00000666423, ENST00000666434, ENST00000666712, ENST00000667051, ENST00000667784, ENST00000668210, ENST00000668713, ENST00000668859, ENST00000670649, ENST00000670981, ENST00000671369, ENST00000731849, ENST00000731850, ENST00000731851, ENST00000731852, ENST00000731853, ENST00000731854, ENST00000731855, ENST00000731856, ENST00000731857, ENST00000731858, ENST00000731859, ENST00000731860, ENST00000731861, ENST00000731862, ENST00000731863, ENST00000731864, ENST00000731865, ENST00000731866, ENST00000731867, ENST00000731868, ENST00000731869, ENST00000731870, ENST00000731871, ENST00000731872, ENST00000731873, ENST00000731874

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000503208 — 4 exons

Exon	Start	End
ENSE00002025579	138032452	138032516
ENSE00002036987	138048380	138048606
ENSE00002064279	138047941	138047977
ENSE00002087397	138049404	138049572

Expression profiles

Bgee: expression breadth broad, 74 present calls, max score 85.86.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.0161 / max 13.9836, expressed in 3 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
53990	0.0161	3

Top tissues by expression

177 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	85.86	gold quality
left testis	UBERON:0004533	75.78	gold quality
right testis	UBERON:0004534	74.73	gold quality
sperm	CL:0000019	74.21	gold quality
testis	UBERON:0000473	73.29	gold quality
buccal mucosa cell	CL:0002336	71.42	silver quality
islet of Langerhans	UBERON:0000006	66.79	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	62.84	gold quality
hindlimb stylopod muscle	UBERON:0004252	62.29	gold quality
sural nerve	UBERON:0015488	62.24	silver quality
pancreas	UBERON:0001264	56.79	gold quality
monocyte	CL:0000576	54.94	gold quality
stromal cell of endometrium	CL:0002255	52.06	silver quality
calcaneal tendon	UBERON:0003701	51.43	silver quality
adenohypophysis	UBERON:0002196	51.27	gold quality
adrenal tissue	UBERON:0018303	50.35	gold quality
tibial nerve	UBERON:0001323	49.75	gold quality
prefrontal cortex	UBERON:0000451	47.67	gold quality
lower lobe of lung	UBERON:0008949	47.62	silver quality
muscle of leg	UBERON:0001383	47.32	gold quality
body of pancreas	UBERON:0001150	46.59	gold quality
tendon of biceps brachii	UBERON:0008188	46.19	gold quality
gastrocnemius	UBERON:0001388	45.94	gold quality
popliteal artery	UBERON:0002250	45.87	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	45.87	silver quality
tibial artery	UBERON:0007610	45.72	gold quality
aorta	UBERON:0000947	45.38	gold quality
anatomical system	UBERON:0000467	45.37	gold quality
right frontal lobe	UBERON:0002810	45.20	gold quality
material anatomical entity	UBERON:0000465	45.13	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	4.88

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Long non-coding RNA LINC00616 promotes ferroptosis of periodontal ligament stem cells via the microRNA-370 / transferrin receptor axis. (PMID:35611986)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.