LINC00619

Summary

LINC00619 (long intergenic non-protein coding RNA 619, HGNC:31657) is a long non-coding RNA gene on chromosome 10q11.21.

At a glance

• GWAS associations: 1

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:31657
Approved symbol	LINC00619
Name	long intergenic non-protein coding RNA 619
Location	10q11.21
Locus type	RNA, long non-coding
Status	Approved
Aliases	bA168P8.1
Entrez	414260
RNAcentral	URS000075C40C — lncRNA, 1131 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 0

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

None — 0 exons

Expression profiles

Top tissues by expression

0 total, by Bgee expression score (0-100, higher = more expressed):

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• LINC00619 restricts gastric cancer progression by preventing microRNA-224-5p-mediated inhibition of OPCML. (PMID:32359894)
• Up-regulation of LINC00619 promotes apoptosis and inhibits proliferation, migration and invasion while promoting apoptosis of osteosarcoma cells through inactivation of the HGF-mediated PI3K-Akt signalling pathway. (PMID:33797312)

Cross-species orthologs

0 orthologs

Protein

Protein identifiers

Canonical reviewed UniProt: None (reviewed: )

All UniProt accessions (0):

RefSeq proteins (0): (*=MANE)

Domains & families (InterPro)

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 0 (showing top):

GO Biological Process (0):

GO Molecular Function (0):

GO Cellular Component (0):

Protein interactions and networks

STRING

0 interactions, top by confidence (×1000):

IntAct

0 interactions, top by confidence:

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

0 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	0
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

0 predictions. Top by Δscore:

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1002089618 (10:43846260 T>C), RS1002409810 (10:43846948 G>T), RS1002524457 (10:43850613 A>G), RS1002756786 (10:43850881 A>G,T), RS1002780321 (10:43845822 T>C), RS1003153090 (10:43844678 G>A,T), RS1004467009 (10:43848196 A>G), RS1005103629 (10:43846292 T>C), RS1005598012 (10:43849421 A>C), RS1005713618 (10:43843989 T>C,G), RS1005731262 (10:43843741 G>A), RS1005860074 (10:43851035 C>T), RS1006124272 (10:43845282 G>A), RS1006246202 (10:43846615 T>C), RS1006514676 (10:43845004 G>A)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

1 associations (top):

Study	Trait	p-value
GCST001762_372	Obesity-related traits	6.000000e-06

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0004344	birth weight

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.