LINC00624

Summary

LINC00624 (long intergenic non-protein coding RNA 624, HGNC:44254) is a long non-coding RNA gene on chromosome 1q21.1-q21.2.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:44254
Approved symbol	LINC00624
Name	long intergenic non-protein coding RNA 624
Location	1q21.1-q21.2
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000278811
Ensembl biotype	lncRNA
Entrez	100289211
RNAcentral	URS000075DFB4 — lncRNA, 3387 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 22 — 22 lncRNA

ENST00000619867, ENST00000621316, ENST00000803843, ENST00000803844, ENST00000803845, ENST00000803846, ENST00000803847, ENST00000803848, ENST00000803849, ENST00000803850, ENST00000803851, ENST00000803852, ENST00000803853, ENST00000803854, ENST00000803855, ENST00000803856, ENST00000803857, ENST00000803858, ENST00000803859, ENST00000803860, ENST00000803861, ENST00000803862

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000619867 — 6 exons

Exon	Start	End
ENSE00003713744	147517443	147517875
ENSE00003715849	147514338	147514448
ENSE00003719076	147515521	147515676
ENSE00003733078	147258885	147260976
ENSE00003740713	147408590	147408689
ENSE00003749892	147384668	147384863

Expression profiles

Bgee: expression breadth ubiquitous, 153 present calls, max score 82.79.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.7528 / max 106.9903, expressed in 103 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
14219	0.7528	103

Top tissues by expression

236 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	82.79	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	75.24	gold quality
buccal mucosa cell	CL:0002336	70.56	gold quality
colonic epithelium	UBERON:0000397	68.90	gold quality
testis	UBERON:0000473	64.97	gold quality
left testis	UBERON:0004533	64.57	gold quality
right testis	UBERON:0004534	63.82	gold quality
bone marrow cell	CL:0002092	63.74	silver quality
stromal cell of endometrium	CL:0002255	60.69	gold quality
ventricular zone	UBERON:0003053	59.55	silver quality
descending thoracic aorta	UBERON:0002345	59.41	gold quality
monocyte	CL:0000576	58.61	gold quality
ganglionic eminence	UBERON:0004023	58.49	gold quality
vermiform appendix	UBERON:0001154	58.44	gold quality
adrenal tissue	UBERON:0018303	57.75	gold quality
thoracic aorta	UBERON:0001515	57.06	gold quality
ascending aorta	UBERON:0001496	56.99	gold quality
right atrium auricular region	UBERON:0006631	56.99	gold quality
popliteal artery	UBERON:0002250	56.94	gold quality
tibial artery	UBERON:0007610	56.93	gold quality
aorta	UBERON:0000947	56.89	gold quality
skin of abdomen	UBERON:0001416	56.70	gold quality
cardiac atrium	UBERON:0002081	56.56	gold quality
medial globus pallidus	UBERON:0002477	56.35	silver quality
rectum	UBERON:0001052	56.34	gold quality
lower lobe of lung	UBERON:0008949	56.14	silver quality
body of uterus	UBERON:0009853	56.07	gold quality
gastrocnemius	UBERON:0001388	55.93	gold quality
muscle of leg	UBERON:0001383	55.75	gold quality
hindlimb stylopod muscle	UBERON:0004252	55.49	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	3.45

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 3)

• Gain of LINC00624 Enhances Liver Cancer Progression by Disrupting the Histone Deacetylase 6/Tripartite Motif Containing 28/Zinc Finger Protein 354C Corepressor Complex. (PMID:32869873)
• Immunosuppressive lncRNA LINC00624 promotes tumor progression and therapy resistance through ADAR1 stabilization. (PMID:36252997)
• LINC00624 affects hepatocellular carcinoma proliferation and apoptosis through the miR-342-3p/DNAJC5 axis. (PMID:38348704)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.