LINC00626

Summary

LINC00626 (long intergenic non-protein coding RNA 626, HGNC:44257) is a long non-coding RNA gene on chromosome 1q24.2.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:44257
Approved symbol	LINC00626
Name	long intergenic non-protein coding RNA 626
Location	1q24.2
Locus type	RNA, long non-coding
Status	Approved
Aliases	MGC4473
Ensembl gene	ENSG00000225826
Ensembl biotype	lncRNA
Entrez	79100
RNAcentral	URS000075C630 — lncRNA, 972 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 6 — 6 lncRNA

ENST00000420691, ENST00000663134, ENST00000665467, ENST00000667346, ENST00000669234, ENST00000670921

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000420691 — 3 exons

Exon	Start	End
ENSE00001611657	168786939	168787228
ENSE00001697463	168792331	168792886
ENSE00001770640	168788781	168788889

Expression profiles

Bgee: expression breadth broad, 72 present calls, max score 98.22.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.0155 / max 17.4717, expressed in 2 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
6498	0.0075	2
6497	0.0041	1
6499	0.0040	1

Top tissues by expression

179 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	98.22	gold quality
ganglionic eminence	UBERON:0004023	60.14	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	54.84	gold quality
gall bladder	UBERON:0002110	54.14	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	53.02	gold quality
monocyte	CL:0000576	51.07	silver quality
adult mammalian kidney	UBERON:0000082	51.05	gold quality
cortex of kidney	UBERON:0001225	50.19	gold quality
islet of Langerhans	UBERON:0000006	50.16	gold quality
right lobe of liver	UBERON:0001114	50.15	silver quality
kidney	UBERON:0002113	48.47	gold quality
right ovary	UBERON:0002118	47.88	gold quality
endometrium	UBERON:0001295	47.53	gold quality
prefrontal cortex	UBERON:0000451	47.40	silver quality
nasal cavity mucosa	UBERON:0001826	46.60	gold quality
left ovary	UBERON:0002119	46.21	gold quality
muscle of leg	UBERON:0001383	46.09	silver quality
vermiform appendix	UBERON:0001154	46.06	gold quality
skin of hip	UBERON:0001554	46.06	silver quality
uterus	UBERON:0000995	45.56	gold quality
adenohypophysis	UBERON:0002196	45.44	gold quality
minor salivary gland	UBERON:0001830	45.27	gold quality
lymph node	UBERON:0000029	44.98	gold quality
pituitary gland	UBERON:0000007	44.57	gold quality
gastrocnemius	UBERON:0001388	44.50	silver quality
metanephros cortex	UBERON:0010533	44.27	gold quality
saliva-secreting gland	UBERON:0001044	44.21	gold quality
mouth mucosa	UBERON:0003729	44.02	gold quality
pancreas	UBERON:0001264	43.98	silver quality
tibial artery	UBERON:0007610	43.65	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	2.96

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• [High LINC00626 expression promotes esophagogastric junction adenocarcinoma metastasis: the mediating role of the JAK1/STAT3/KHSRP axis]. (PMID:38597446)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.