LINC00628

Summary

LINC00628 (long intergenic non-protein coding RNA 628, HGNC:27008) is a long non-coding RNA gene on chromosome 1q32.1.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:27008
Approved symbol	LINC00628
Name	long intergenic non-protein coding RNA 628
Location	1q32.1
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000280924
Ensembl biotype	lncRNA
Entrez	127841
RNAcentral	URS000075AA5E — lncRNA, 1290 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 lncRNA

ENST00000628516

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000628516 — 1 exons

Exon	Start	End
ENSE00003771018	204368431	204369719

Expression profiles

Bgee: expression breadth broad, 56 present calls, max score 84.77.

Top tissues by expression

160 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
skeletal muscle tissue of rectus abdominis	UBERON:0004511	84.77	gold quality
myocardium	UBERON:0002349	75.87	gold quality
sperm	CL:0000019	75.41	gold quality
skeletal muscle tissue	UBERON:0001134	72.03	gold quality
lower lobe of lung	UBERON:0008949	71.22	silver quality
vena cava	UBERON:0004087	70.85	gold quality
gingival epithelium	UBERON:0001949	70.81	gold quality
gingiva	UBERON:0001828	70.33	gold quality
skeletal muscle tissue of biceps brachii	UBERON:0004502	69.95	gold quality
superficial temporal artery	UBERON:0001614	69.50	gold quality
mucosa of sigmoid colon	UBERON:0004993	69.06	gold quality
decidua	UBERON:0002450	69.00	gold quality
quadriceps femoris	UBERON:0001377	67.40	gold quality
vastus lateralis	UBERON:0001379	67.33	gold quality
cardia of stomach	UBERON:0001162	67.16	gold quality
body of tongue	UBERON:0011876	67.13	gold quality
tendon of biceps brachii	UBERON:0008188	67.10	gold quality
bone marrow	UBERON:0002371	67.09	gold quality
tongue	UBERON:0001723	67.01	gold quality
coronary artery	UBERON:0001621	66.97	gold quality
trachea	UBERON:0003126	66.89	gold quality
corpus callosum	UBERON:0002336	66.86	gold quality
pons	UBERON:0000988	66.82	gold quality
tonsil	UBERON:0002372	66.82	gold quality
saphenous vein	UBERON:0007318	66.70	gold quality
pericardium	UBERON:0002407	66.68	gold quality
subthalamic nucleus	UBERON:0001906	66.63	gold quality
biceps brachii	UBERON:0001507	66.61	gold quality
pharyngeal mucosa	UBERON:0000355	66.58	gold quality
superior surface of tongue	UBERON:0007371	66.52	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.86

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 3)

• confirmed that LINC00628 mainly located in the nucleus and interacted with EZH2, and modulated genes expression by regulating H3K27me3 level (PMID:27272474)
• Results demostrated that LINC00628 expression was decreased in osteosarcoma. The overexpression of LINC00628 inhibited the proliferation, invasion and migration and promoted cell apoptosis in osteosarcoma cells through the inactivation of PI3K/Akt signaling pathway. The study indicated that LINC00628 may be a biomarker for the prognosis of osteosarcoma patients. (PMID:30280767)
• Downregulated LINC00628 aggravates the progression of colorectal cancer via inhibiting p57 level. (PMID:32141544)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.