LINC00629

Summary

LINC00629 (long intergenic non-protein coding RNA 629, HGNC:44262) is a long non-coding RNA gene on chromosome Xq26.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:44262
Approved symbol	LINC00629
Name	long intergenic non-protein coding RNA 629
Location	Xq26.3
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000227060
Ensembl biotype	lncRNA
Entrez	100506757
RNAcentral	URS000075BA7E — lncRNA, 1333 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 12 — 12 lncRNA

ENST00000434384, ENST00000592070, ENST00000652893, ENST00000654989, ENST00000657735, ENST00000659711, ENST00000671142, ENST00000671259, ENST00000809803, ENST00000809804, ENST00000809805, ENST00000809806

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000434384 — 3 exons

Exon	Start	End
ENSE00001648656	134558380	134558497
ENSE00004205970	134549783	134550040
ENSE00004205984	134559386	134560391

Expression profiles

Bgee: expression breadth ubiquitous, 143 present calls, max score 78.16.

Top tissues by expression

237 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	78.16	gold quality
hindlimb stylopod muscle	UBERON:0004252	75.01	gold quality
colonic epithelium	UBERON:0000397	74.13	gold quality
cortical plate	UBERON:0005343	65.51	gold quality
stromal cell of endometrium	CL:0002255	65.21	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	64.07	gold quality
left ovary	UBERON:0002119	63.21	gold quality
heart left ventricle	UBERON:0002084	62.95	gold quality
endocervix	UBERON:0000458	62.63	gold quality
cardiac ventricle	UBERON:0002082	62.18	gold quality
left uterine tube	UBERON:0001303	62.06	gold quality
right uterine tube	UBERON:0001302	61.95	gold quality
right ovary	UBERON:0002118	61.50	gold quality
ovary	UBERON:0000992	61.27	gold quality
tibialis anterior	UBERON:0001385	60.98	silver quality
adrenal tissue	UBERON:0018303	60.23	gold quality
upper leg skin	UBERON:0004262	59.99	gold quality
fallopian tube	UBERON:0003889	59.74	gold quality
ectocervix	UBERON:0012249	59.18	gold quality
uterine cervix	UBERON:0000002	59.05	gold quality
endothelial cell	CL:0000115	58.84	gold quality
apex of heart	UBERON:0002098	58.01	gold quality
body of uterus	UBERON:0009853	57.94	gold quality
prefrontal cortex	UBERON:0000451	57.88	gold quality
heart	UBERON:0000948	57.88	gold quality
oviduct epithelium	UBERON:0004804	57.53	silver quality
pancreatic ductal cell	CL:0002079	57.37	silver quality
muscle of leg	UBERON:0001383	57.02	gold quality
ileal mucosa	UBERON:0000331	56.22	silver quality
gastrocnemius	UBERON:0001388	55.72	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.30

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 4)

• lincRNAs MIR503HG and LINC00629 impaired migration and invasion capacities in a choriocarcinoma in vitro model, indicating a potential role in human reproduction and tumorigenesis. (PMID:27023770)
• Long noncoding RNA LINC00629 restrains the progression of gastric cancer by upregulating AQP4 through competitively binding to miR-196b-5p. (PMID:31674022)
• LINC00629 protects osteosarcoma cell from ER stress-induced apoptosis and facilitates tumour progression by elevating KLF4 stability. (PMID:36539799)
• LINC00629, a HOXB4-downregulated long noncoding RNA, inhibits glycolysis and ovarian cancer progression by destabilizing c-Myc. (PMID:38182548)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.