LINC00630

Summary

LINC00630 (long intergenic non-protein coding RNA 630, HGNC:44263) is a long non-coding RNA gene on chromosome Xq22.1.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:44263
Approved symbol	LINC00630
Name	long intergenic non-protein coding RNA 630
Location	Xq22.1
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000223546
Ensembl biotype	lncRNA
Entrez	100287765
RNAcentral	URS0000BC43C6 — lncRNA, 3492 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 71 — 71 lncRNA

ENST00000416381, ENST00000420471, ENST00000426528, ENST00000429932, ENST00000431616, ENST00000435966, ENST00000440496, ENST00000656628, ENST00000658813, ENST00000658880, ENST00000661018, ENST00000663114, ENST00000664568, ENST00000666631, ENST00000668536, ENST00000670178, ENST00000688915, ENST00000717311, ENST00000717312, ENST00000717313, ENST00000717314, ENST00000717315, ENST00000717316, ENST00000780028, ENST00000780029, ENST00000780030, ENST00000780031, ENST00000780032, ENST00000780033, ENST00000780034, ENST00000780035, ENST00000780036, ENST00000780037, ENST00000780038, ENST00000780039, ENST00000780040, ENST00000780041, ENST00000780042, ENST00000780043, ENST00000780044, ENST00000780045, ENST00000780046, ENST00000780047, ENST00000780048, ENST00000780049, ENST00000780050, ENST00000780051, ENST00000780052, ENST00000780053, ENST00000780054, ENST00000780055, ENST00000780056, ENST00000780057, ENST00000780058, ENST00000780059, ENST00000780060, ENST00000780061, ENST00000780062, ENST00000780063, ENST00000780064, ENST00000780065, ENST00000780066, ENST00000780067, ENST00000780068, ENST00000780069, ENST00000780070, ENST00000780071, ENST00000780072, ENST00000780073, ENST00000780074, ENST00000780075

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000416381 — 7 exons

Exon	Start	End
ENSE00001615322	102826969	102827144
ENSE00001651114	102845857	102846020
ENSE00001767260	102770352	102770420
ENSE00001771561	102816992	102817082
ENSE00004032191	102865042	102866824
ENSE00004032192	102769207	102769341
ENSE00004032206	102839801	102839972

Expression profiles

Bgee: expression breadth ubiquitous, 164 present calls, max score 85.55.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 6.3402 / max 86.1217, expressed in 1638 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
196998	6.3402	1638

Top tissues by expression

246 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
colonic epithelium	UBERON:0000397	85.55	gold quality
calcaneal tendon	UBERON:0003701	83.80	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	83.56	gold quality
bone marrow cell	CL:0002092	82.66	gold quality
adrenal tissue	UBERON:0018303	80.14	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	78.18	gold quality
cortical plate	UBERON:0005343	77.54	gold quality
stromal cell of endometrium	CL:0002255	77.17	gold quality
ventricular zone	UBERON:0003053	75.74	gold quality
ganglionic eminence	UBERON:0004023	75.02	gold quality
secondary oocyte	CL:0000655	74.48	gold quality
islet of Langerhans	UBERON:0000006	72.49	gold quality
smooth muscle tissue	UBERON:0001135	71.56	gold quality
sural nerve	UBERON:0015488	71.11	gold quality
buccal mucosa cell	CL:0002336	71.07	gold quality
body of uterus	UBERON:0009853	70.55	gold quality
left ovary	UBERON:0002119	70.30	gold quality
prefrontal cortex	UBERON:0000451	70.01	gold quality
ectocervix	UBERON:0012249	69.80	gold quality
uterine cervix	UBERON:0000002	69.35	gold quality
tonsil	UBERON:0002372	69.20	gold quality
left lobe of thyroid gland	UBERON:0001120	68.91	gold quality
pancreas	UBERON:0001264	68.89	gold quality
thyroid gland	UBERON:0002046	68.52	gold quality
right ovary	UBERON:0002118	68.52	gold quality
right lobe of thyroid gland	UBERON:0001119	68.32	gold quality
endocervix	UBERON:0000458	68.30	gold quality
mucosa of stomach	UBERON:0001199	68.06	gold quality
popliteal artery	UBERON:0002250	67.99	gold quality
tibial artery	UBERON:0007610	67.99	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	4.26

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• we characterized the lncRNA linc00630 as a novel tumor oncogene in Non-Small-Cell Lung Cancers (PMID:28473661)
• Long noncoding RNA LINC00630 promotes radio-resistance by regulating BEX1 gene methylation in colorectal cancer cells. (PMID:32119177)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.