LINC00632

Summary

LINC00632 (long intergenic non-protein coding RNA 632, HGNC:27865) is a long non-coding RNA gene on chromosome Xq27.1.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:27865
Approved symbol	LINC00632
Name	long intergenic non-protein coding RNA 632
Location	Xq27.1
Locus type	RNA, long non-coding
Status	Approved
Aliases	ASINC, ARST, CDR1NAT, ciRS-7, CDR1as, MDHDH
Ensembl gene	ENSG00000203930
Ensembl biotype	lncRNA
OMIM	301147
Entrez	286411
RNAcentral	URS000075E7FE — lncRNA, 1398 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 33 — 33 lncRNA

ENST00000370535, ENST00000498732, ENST00000602535, ENST00000602830, ENST00000607004, ENST00000625883, ENST00000647853, ENST00000647949, ENST00000648186, ENST00000648200, ENST00000648347, ENST00000648508, ENST00000648876, ENST00000649160, ENST00000649192, ENST00000649329, ENST00000649333, ENST00000649335, ENST00000649535, ENST00000650090, ENST00000650128, ENST00000650158, ENST00000650391, ENST00000650438, ENST00000650626, ENST00000658451, ENST00000659304, ENST00000660897, ENST00000669839, ENST00000715257, ENST00000718126, ENST00000746348, ENST00000746349

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000370535 — 3 exons

Exon	Start	End
ENSE00001452961	140713495	140714848
ENSE00001452963	140709767	140709805
ENSE00003732062	140711621	140711656

Expression profiles

Bgee: expression breadth ubiquitous, 191 present calls, max score 99.37.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 68.0889 / max 16770.7133, expressed in 1093 samples.

FANTOM5 promoters (32 alternative TSS)

Promoter ID	TPM avg	Samples expressed
197851	15.8441	811
197846	14.7275	815
197753	10.2228	359
197856	5.2379	561
197855	4.4668	477
197844	3.3214	755
197850	2.2385	323
197848	1.9440	266
197756	1.8455	169
197854	1.6757	277

Top tissues by expression

244 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
colonic epithelium	UBERON:0000397	99.37	gold quality
calcaneal tendon	UBERON:0003701	99.10	gold quality
sural nerve	UBERON:0015488	98.97	gold quality
cerebellar cortex	UBERON:0002129	98.71	gold quality
cerebellar hemisphere	UBERON:0002245	98.70	gold quality
cerebellum	UBERON:0002037	98.56	gold quality
right hemisphere of cerebellum	UBERON:0014890	98.10	gold quality
putamen	UBERON:0001874	97.91	gold quality
caudate nucleus	UBERON:0001873	97.03	gold quality
pituitary gland	UBERON:0000007	95.90	gold quality
corpus callosum	UBERON:0002336	95.47	gold quality
nucleus accumbens	UBERON:0001882	94.86	gold quality
amygdala	UBERON:0001876	94.63	gold quality
adenohypophysis	UBERON:0002196	94.47	gold quality
superior vestibular nucleus	UBERON:0007227	94.13	gold quality
cerebellar vermis	UBERON:0004720	93.96	gold quality
substantia nigra pars compacta	UBERON:0001965	93.49	gold quality
anterior cingulate cortex	UBERON:0009835	93.35	gold quality
Ammon’s horn	UBERON:0001954	93.29	gold quality
brain	UBERON:0000955	93.01	gold quality
pons	UBERON:0000988	92.78	gold quality
parietal lobe	UBERON:0001872	92.71	gold quality
medulla oblongata	UBERON:0001896	92.62	gold quality
postcentral gyrus	UBERON:0002581	92.42	gold quality
forebrain	UBERON:0001890	92.32	gold quality
hypothalamus	UBERON:0001898	92.26	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	92.26	gold quality
superior frontal gyrus	UBERON:0002661	92.13	gold quality
lateral nuclear group of thalamus	UBERON:0002736	91.71	gold quality
occipital lobe	UBERON:0002021	91.57	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 2.

Experiment	Marker?	Max mean expression
E-HCAD-25	yes	80.92
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 5)

• LINC00632 inhibits the malignant development of non-small cell lung cancer by downregulating miR-1203. (PMID:32862599)
• A novel lncRNA ARST represses glioma progression by inhibiting ALDOA-mediated actin cytoskeleton integrity. (PMID:34099027)
• Mesenchymal Stem Cell-Derived Exosome-Containing Linc00632 Regulates GATA Binding Protein-3 Expression in Allergic Rhinitis by Interacting with Enhancer of Zeste Homolog 2 to Inhibit T Helper Cell 2 Differentiation. (PMID:34537772)
• A brain-enriched lncRNA shields cancer cells from immune-mediated killing for metastatic colonization in the brain. (PMID:35617432)
• LINC00632 relates to milder Th1/Th2 imbalance, attenuated nasal symptoms, and better response to therapy in allergic rhinitis patients. (PMID:36916096)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.