LINC00641

Summary

LINC00641 (long intergenic non-protein coding RNA 641, HGNC:27511) is a long non-coding RNA gene on chromosome 14q11.2.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:27511
Approved symbol	LINC00641
Name	long intergenic non-protein coding RNA 641
Location	14q11.2
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000258441
Ensembl biotype	lncRNA
Entrez	283624
RNAcentral	URS000075E871 — lncRNA, 5439 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 2 — 1 retained_intron, 1 lncRNA

ENST00000555379, ENST00000555688

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000555379 — 1 exons

Exon	Start	End
ENSE00002483429	21200079	21205503

Expression profiles

Bgee: expression breadth ubiquitous, 167 present calls, max score 95.33.

Top tissues by expression

246 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
cortical plate	UBERON:0005343	95.33	gold quality
Brodmann (1909) area 9	UBERON:0013540	94.51	gold quality
cerebellar hemisphere	UBERON:0002245	93.83	gold quality
cerebellar cortex	UBERON:0002129	93.76	gold quality
anterior cingulate cortex	UBERON:0009835	93.53	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	92.81	gold quality
right hemisphere of cerebellum	UBERON:0014890	92.54	gold quality
right frontal lobe	UBERON:0002810	91.76	gold quality
prefrontal cortex	UBERON:0000451	90.57	gold quality
hypothalamus	UBERON:0001898	90.48	gold quality
cerebellum	UBERON:0002037	90.19	gold quality
ganglionic eminence	UBERON:0004023	89.84	gold quality
amygdala	UBERON:0001876	89.75	gold quality
nucleus accumbens	UBERON:0001882	89.27	gold quality
putamen	UBERON:0001874	89.24	gold quality
caudate nucleus	UBERON:0001873	88.70	gold quality
spinal cord	UBERON:0002240	88.12	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	86.77	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	86.20	gold quality
neocortex	UBERON:0001950	84.98	gold quality
tibial nerve	UBERON:0001323	84.93	gold quality
lower esophagus muscularis layer	UBERON:0035833	84.53	gold quality
muscle layer of sigmoid colon	UBERON:0035805	84.52	gold quality
lower esophagus	UBERON:0013473	84.50	gold quality
tibial artery	UBERON:0007610	84.35	gold quality
popliteal artery	UBERON:0002250	84.32	gold quality
mucosa of stomach	UBERON:0001199	84.14	gold quality
left uterine tube	UBERON:0001303	84.14	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	84.01	gold quality
frontal cortex	UBERON:0001870	83.65	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	7.98

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 14)

• study illustrated a novel signaling cascade of LINC00641/miR-197-3p/KLF10/PTEN/PI3K/AKT pathway regulating bladder cancer development (PMID:30060954)
• LINC00641 targets miR-153-3p, and thus affects ATG5 expression, and autophagic cell death in intervertebral disc degeneration. (PMID:30378116)
• LINC00641 suppressed cell proliferation and induced cell apoptosis in NSCLC, indicating that LINC00641 exerted tumor-suppressive role in NSCLC. Through mechanism investigation, we determined that LINC00641 acted as a competing endogenous RNA (ceRNA) in NSCLC by sponging miR-424-5p to upregulate phospholipid scramblase (PLSCR4) expression. (PMID:31322545)
• Long intergenic noncoding RNA 00641 inhibits breast cancer cell proliferation, migration, and invasion by sponging miR-194-5p. (PMID:31490021)
• Long non-coding RNA LINC00641 promotes cell growth and migration through modulating miR-378a/ZBTB20 axis in acute myeloid leukemia. (PMID:31539138)
• LINC00641 hinders the progression of cervical cancer by targeting miR-378a-3p/CPEB3. (PMID:32367630)
• LINC00641/miR-582-5p mediate oxaliplatin resistance by activating autophagy in gastric adenocarcinoma. (PMID:32917936)
• LINC00641 regulates prostate cancer cell growth and apoptosis via the miR-365a-3p/VGLL4 axis. (PMID:33506898)
• LINC00641 induces the malignant progression of colorectal carcinoma through the miRNA-424-5p/PLSCR4 feedback loop. (PMID:33577029)
• Linc00641 promotes the progression of gastric carcinoma by modulating the miR-429/Notch-1 axis. (PMID:33714199)
• LINC00641 Inhibits the Development of Cutaneous Squamous Cell Carcinoma By Downregulating miR-424 in A431 Cells. (PMID:33885353)
• LINC00641 contributes to nasopharyngeal carcinoma cell malignancy through FOXD1 upregulation at the post-transcriptional level. (PMID:34767742)
• Long non-coding RNA long intergenic non-coding 00641 mediates cell progression with stimulating cisplatin-resistance in osteosarcoma cells via microRNA-320d/myeloid cell leukemia-1 axis. (PMID:35266447)
• Prognostic utility of lncRNAs (LINC00565 and LINC00641) as molecular markers in glioblastoma multiforme (GBM). (PMID:35668225)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.