LINC00645

Summary

LINC00645 (long intergenic non-protein coding RNA 645, HGNC:44299) is a long non-coding RNA gene on chromosome 14q12.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:44299
Approved symbol	LINC00645
Name	long intergenic non-protein coding RNA 645
Location	14q12
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000258548
Ensembl biotype	lncRNA
Entrez	100505967
RNAcentral	URS000075E5F2 — lncRNA, 3555 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 9 — 9 lncRNA

ENST00000555350, ENST00000557359, ENST00000557399, ENST00000662039, ENST00000662633, ENST00000663380, ENST00000669384, ENST00000794993, ENST00000794994

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000555350 — 2 exons

Exon	Start	End
ENSE00002471549	27636420	27636669
ENSE00002473081	27634125	27634344

Expression profiles

Bgee: expression breadth ubiquitous, 102 present calls, max score 88.45.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.1329 / max 43.9088, expressed in 39 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
139062	0.1042	34
139063	0.0287	15

Top tissues by expression

199 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
pigmented layer of retina	UBERON:0001782	88.45	gold quality
bone marrow cell	CL:0002092	83.09	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	81.83	gold quality
renal medulla	UBERON:0000362	80.88	gold quality
kidney	UBERON:0002113	76.76	gold quality
adult mammalian kidney	UBERON:0000082	75.35	gold quality
cortex of kidney	UBERON:0001225	74.96	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	73.86	gold quality
metanephros cortex	UBERON:0010533	67.37	gold quality
nucleus accumbens	UBERON:0001882	66.53	gold quality
endometrium	UBERON:0001295	64.64	gold quality
metanephros	UBERON:0000081	64.16	gold quality
ventricular zone	UBERON:0003053	62.00	gold quality
caudate nucleus	UBERON:0001873	60.69	gold quality
hindlimb stylopod muscle	UBERON:0004252	60.59	gold quality
ganglionic eminence	UBERON:0004023	60.44	gold quality
cortical plate	UBERON:0005343	60.22	gold quality
uterus	UBERON:0000995	59.19	gold quality
hypothalamus	UBERON:0001898	58.93	gold quality
calcaneal tendon	UBERON:0003701	58.75	gold quality
monocyte	CL:0000576	55.51	gold quality
putamen	UBERON:0001874	55.35	gold quality
prefrontal cortex	UBERON:0000451	54.11	gold quality
muscle of leg	UBERON:0001383	52.72	gold quality
female reproductive system	UBERON:0000474	52.24	gold quality
gastrocnemius	UBERON:0001388	52.05	gold quality
tendon	UBERON:0000043	51.21	gold quality
forebrain	UBERON:0001890	50.59	gold quality
adrenal tissue	UBERON:0018303	50.55	gold quality
brain	UBERON:0000955	50.14	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	3.56

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• LINC00645 inhibits renal cell carcinoma progression by interacting with HNRNPA2B1 to regulate the ROCK1 mRNA stability. (PMID:38309317)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.