LINC00659

Summary

LINC00659 (long intergenic non-protein coding RNA 659, HGNC:44316) is a long non-coding RNA gene on chromosome 20q13.33.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:44316
Approved symbol	LINC00659
Name	long intergenic non-protein coding RNA 659
Location	20q13.33
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000228705
Ensembl biotype	lncRNA
Entrez	100652730
RNAcentral	URS000075C81C — lncRNA, 706 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 24 — 24 lncRNA

ENST00000412500, ENST00000653007, ENST00000655940, ENST00000657741, ENST00000658688, ENST00000658884, ENST00000667589, ENST00000667978, ENST00000689171, ENST00000701965, ENST00000764050, ENST00000764051, ENST00000764052, ENST00000764053, ENST00000764054, ENST00000764055, ENST00000764056, ENST00000764057, ENST00000764058, ENST00000764059, ENST00000764060, ENST00000764061, ENST00000764062, ENST00000764063

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000412500 — 2 exons

Exon	Start	End
ENSE00003859768	62774121	62774569
ENSE00004120683	62775315	62776954

Expression profiles

Bgee: expression breadth ubiquitous, 101 present calls, max score 81.54.

FANTOM5 (CAGE): breadth broad, TPM avg 1.1193 / max 89.1489, expressed in 288 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
188300	0.4867	80
188301	0.3205	144
188302	0.3121	179

Top tissues by expression

101 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right lobe of liver	UBERON:0001114	81.54	gold quality
bone marrow cell	CL:0002092	77.63	silver quality
liver	UBERON:0002107	77.62	gold quality
duodenum	UBERON:0002114	75.91	gold quality
muscle tissue	UBERON:0002385	73.78	gold quality
kidney	UBERON:0002113	67.80	gold quality
cortex of kidney	UBERON:0001225	67.71	gold quality
adult mammalian kidney	UBERON:0000082	67.42	gold quality
metanephros cortex	UBERON:0010533	64.99	gold quality
hindlimb stylopod muscle	UBERON:0004252	63.75	gold quality
blood	UBERON:0000178	63.64	gold quality
myometrium	UBERON:0001296	62.97	gold quality
bone marrow	UBERON:0002371	62.89	gold quality
body of stomach	UBERON:0001161	61.05	gold quality
stomach	UBERON:0000945	60.25	gold quality
fundus of stomach	UBERON:0001160	58.83	gold quality
granulocyte	CL:0000094	57.32	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	56.66	silver quality
leukocyte	CL:0000738	55.41	gold quality
islet of Langerhans	UBERON:0000006	54.95	gold quality
pancreas	UBERON:0001264	54.59	gold quality
right testis	UBERON:0004534	54.48	gold quality
prefrontal cortex	UBERON:0000451	54.34	gold quality
left testis	UBERON:0004533	54.28	gold quality
testis	UBERON:0000473	54.26	gold quality
tonsil	UBERON:0002372	54.23	gold quality
body of pancreas	UBERON:0001150	54.17	gold quality
monocyte	CL:0000576	54.02	gold quality
lymph node	UBERON:0000029	53.97	gold quality
ovary	UBERON:0000992	53.61	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.42

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 9)

• Linc00659 is a novel oncogenic lncRNA involved in colon cancer cell growth by modulating the cell cycle. (PMID:29523145)
• Correlation between LncRNA-LINC00659 and clinical prognosis in gastric cancer and study on its biological mechanism. (PMID:33145980)
• Exosomal LncRNA LINC00659 transferred from cancer-associated fibroblasts promotes colorectal cancer cell progression via miR-342-3p/ANXA2 axis. (PMID:33407563)
• SP1-Induced Upregulation of lncRNA LINC00659 Promotes Tumour Progression in Gastric Cancer by Regulating miR-370/AQP3 Axis. (PMID:35957833)
• By modulating miR-525-5p/Bax axis, LINC00659 promotes vascular endothelial cell apoptosis. (PMID:36705418)
• LINC00659 cooperated with ALKBH5 to accelerate gastric cancer progression by stabilising JAK1 mRNA in an m[6] A-YTHDF2-dependent manner. (PMID:36864711)
• LINC00659 Inhibits Hepatocellular Carcinoma Malignant Progression by Blocking Aerobic Glycolysis through FUS Recruitment and SLC10A1 Modulation. (PMID:37234237)
• Long non-coding RNA linc00659 promotes tumour progression by regulating FZD6/Wnt/beta-catenin signalling pathway in colorectal cancer via m6A reader IGF2BP1. (PMID:38009760)
• Upregulated LncRNA-LINC00659 expression by H. pylori infection promoted the progression of gastritis to cancer by regulating PTBP1 expression. (PMID:38394397)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.