LINC00662

Summary

LINC00662 (long intergenic non-protein coding RNA 662, HGNC:27122) is a long non-coding RNA gene on chromosome 19q11.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:27122
Approved symbol	LINC00662
Name	long intergenic non-protein coding RNA 662
Location	19q11
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000261824
Ensembl biotype	lncRNA
Entrez	148189
RNAcentral	URS000075BAA8 — lncRNA, 2085 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 93 — 93 lncRNA

ENST00000561521, ENST00000586248, ENST00000586954, ENST00000588027, ENST00000588150, ENST00000590523, ENST00000590677, ENST00000591338, ENST00000591458, ENST00000653317, ENST00000653404, ENST00000653459, ENST00000653471, ENST00000654098, ENST00000654151, ENST00000654443, ENST00000654565, ENST00000654892, ENST00000655066, ENST00000655166, ENST00000655465, ENST00000655567, ENST00000656086, ENST00000656170, ENST00000656191, ENST00000656221, ENST00000656647, ENST00000656708, ENST00000656728, ENST00000657659, ENST00000657677, ENST00000657730, ENST00000658434, ENST00000658654, ENST00000658694, ENST00000658794, ENST00000659364, ENST00000659422, ENST00000659734, ENST00000659785, ENST00000659922, ENST00000659995, ENST00000660418, ENST00000660820, ENST00000661680, ENST00000662444, ENST00000662487, ENST00000663492, ENST00000663775, ENST00000664204, ENST00000664383, ENST00000664444, ENST00000664688, ENST00000664720, ENST00000664921, ENST00000665102, ENST00000665874, ENST00000665996, ENST00000666003, ENST00000666409, ENST00000666658, ENST00000666734, ENST00000666841, ENST00000667396, ENST00000667518, ENST00000667678, ENST00000668068, ENST00000668513, ENST00000668560, ENST00000668933, ENST00000669191, ENST00000670305, ENST00000670572, ENST00000670973, ENST00000671152, ENST00000671227, ENST00000671282, ENST00000687807, ENST00000690193, ENST00000690384, ENST00000749058, ENST00000749059, ENST00000749060, ENST00000749061, ENST00000749062, ENST00000749063, ENST00000749064, ENST00000749065, ENST00000749066, ENST00000749067, ENST00000749068, ENST00000749069, ENST00000749070

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000561521 — 4 exons

Exon	Start	End
ENSE00002605939	27732796	27732967
ENSE00002894924	27746098	27746340
ENSE00003987350	27730273	27732447
ENSE00003987351	27793000	27793195

Expression profiles

Bgee: expression breadth ubiquitous, 212 present calls, max score 95.65.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 27.8853 / max 1250.5871, expressed in 1736 samples.

FANTOM5 promoters (9 alternative TSS)

Promoter ID	TPM avg	Samples expressed
180327	10.9580	1090
180328	7.7634	1381
180332	5.3134	1619
180326	1.4918	276
180331	1.3328	689
180324	0.5251	107
180330	0.2258	119
180325	0.1760	76
180329	0.0990	37

Top tissues by expression

240 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
buccal mucosa cell	CL:0002336	95.65	gold quality
cortical plate	UBERON:0005343	92.08	gold quality
left testis	UBERON:0004533	87.95	gold quality
right testis	UBERON:0004534	87.75	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	87.63	gold quality
calcaneal tendon	UBERON:0003701	87.10	gold quality
testis	UBERON:0000473	87.06	gold quality
sural nerve	UBERON:0015488	86.95	gold quality
ganglionic eminence	UBERON:0004023	86.81	gold quality
pancreatic ductal cell	CL:0002079	86.32	gold quality
Brodmann (1909) area 9	UBERON:0013540	86.25	gold quality
sperm	CL:0000019	85.56	gold quality
anterior cingulate cortex	UBERON:0009835	84.92	gold quality
right frontal lobe	UBERON:0002810	84.79	gold quality
cerebellar cortex	UBERON:0002129	84.53	gold quality
cerebellar hemisphere	UBERON:0002245	84.52	gold quality
ventricular zone	UBERON:0003053	84.34	gold quality
hypothalamus	UBERON:0001898	84.27	gold quality
right hemisphere of cerebellum	UBERON:0014890	84.02	gold quality
cerebellum	UBERON:0002037	83.76	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	83.73	gold quality
tendon	UBERON:0000043	83.42	gold quality
hindlimb stylopod muscle	UBERON:0004252	83.30	gold quality
kidney epithelium	UBERON:0004819	82.69	gold quality
amygdala	UBERON:0001876	82.48	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	82.45	gold quality
muscle of leg	UBERON:0001383	82.44	gold quality
nucleus accumbens	UBERON:0001882	82.37	gold quality
adrenal tissue	UBERON:0018303	82.28	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	82.02	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	4.65

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 25)

• Data suggest that overexpression of Linc00662 enhances lung cancer cell metastasis and cancer stem cell characteristics; these characteristics seem to involve interaction of Linc00662 with LIN28 in lung cancer cells; lung cancer patients with higher Linc00662 expression levels exhibit lower overall survival rate than patients with lower Linc00662 expression levels. (LIN28 = RNA-binding protein LIN-28) (PMID:30256974)
• critical role for the LINC00662-miR-497-5p-YAP1 axis in gastric cancer cell growth (PMID:30297104)
• Long noncoding RNA LINC00662 functions as miRNA sponge to promote the prostate cancer tumorigenesis through targeting miR-34a. (PMID:31114993)
• the important role of the LINC00662/miR-340-5p/ROCK1 axis in regulating the malignant behavior of AML cells (PMID:31306637)
• Long noncoding RNA LINC00662 promotes M2 macrophage polarization and hepatocellular carcinoma progression via activating Wnt/beta-catenin signaling. (PMID:31785055)
• Long noncoding RNA LINC00662-miR-15b-5p mediated GPR120 dysregulation contributes to osteoarthritis. (PMID:32037689)
• LINC00662 triggers malignant progression of chordoma by the activation of RNF144B via targeting miR-16-5p. (PMID:32096180)
• TRA2A-induced upregulation of LINC00662 regulates blood-brain barrier permeability by affecting ELK4 mRNA stability in Alzheimer’s microenvironment. (PMID:32372707)
• LINC00662 promotes glycolysis and cell survival by regulating miR- 375/HIF-1alpha axis in ovarian cancer. (PMID:32476381)
• Long non-coding RNA LINC00662 promotes proliferation and migration of breast cancer cells via regulating the miR-497-5p/EglN2 axis. (PMID:32558530)
• LINC00662 contributes to the progression and the radioresistance of cervical cancer by regulating miR-497-5p and CDC25A. (PMID:32869878)
• LINC00662 promotes cell proliferation, migration and invasion of melanoma by sponging miR-890 to upregulate ELK3. (PMID:32894549)
• Silencing linc00662 inhibits cell proliferation and colony formation of lung cancer cells via regulating the miR-145-5p-PAFAH1B2 axis. (PMID:33108738)
• [Long noncoding RNA Linc00662 promotes the tumorigenesis of prostate cancer cells]. (PMID:33377712)
• Exosomal long non-coding RNA LINC00662 promotes non-small cell lung cancer progression by miR-320d/E2F1 axis. (PMID:33589572)
• LINC00662 modulates cervical cancer cell proliferation, invasion, and apoptosis via sponging miR-103a-3p and upregulating PDK4. (PMID:33819358)
• LINC00662 Promotes Oral Squamous Cell Carcinoma Cell Growth and Metastasis through miR-144-3p/EZH2 Axis. (PMID:34164962)
• A positive feedback loop of LINC00662 and STAT3 promotes malignant phenotype of glioma. (PMID:34246852)
• LINC00662 facilitates osteosarcoma progression via sponging miR-103a-3p and regulating SIK2 expression. (PMID:34559955)
• Long intergenic non-protein coding RNA 662 accelerates the progression of gastric cancer through up-regulating centrosomal protein 55 by sponging microRNA-195-5p. (PMID:35037833)
• LINC00662 Promotes Proliferation and Invasion and Inhibits Apoptosis of Glioma Cells Through miR-483-3p/SOX3 Axis. (PMID:35275355)
• METTL3/LINC00662/miR-186-5p feedback loop regulates docetaxel resistance in triple negative breast cancer. (PMID:36202872)
• The role and mechanisms of long non-coding RNA LINC00662 in promoting the proliferation, migration, and angiogenesis of BGC-823 and HGC-27 cells and the subsequent effect on the progression of gastric cancer. (PMID:37087562)
• LINC00662 promotes melanoma progression by competitively binding miR-107 and activating the beta-catenin signaling pathway. (PMID:38169586)
• LINC00662 Promotes Aggressive Traits by Modulating OCT4 Expression through miR-335-5p in Gallbladder Cancer Cells. (PMID:38928444)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.