LINC00663

Summary

LINC00663 (long intergenic non-protein coding RNA 663, HGNC:28609) is a long non-coding RNA gene on chromosome 19p13.11.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:28609
Approved symbol	LINC00663
Name	long intergenic non-protein coding RNA 663
Location	19p13.11
Locus type	RNA, long non-coding
Status	Approved
Aliases	MGC39821
Ensembl gene	ENSG00000266904
Ensembl biotype	lncRNA
OMIM	617117
Entrez	284440
RNAcentral	URS000075C943 — lncRNA, 2385 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 20 — 20 lncRNA

ENST00000586645, ENST00000586816, ENST00000586885, ENST00000588223, ENST00000589508, ENST00000589910, ENST00000590092, ENST00000651161, ENST00000703445, ENST00000715981, ENST00000715982, ENST00000715983, ENST00000715999, ENST00000716000, ENST00000716001, ENST00000716002, ENST00000716003, ENST00000716004, ENST00000716005, ENST00000716006

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000586645 — 3 exons

Exon	Start	End
ENSE00003553093	19762538	19762646
ENSE00004028511	19757366	19758546
ENSE00004028517	19776327	19776393

Expression profiles

Bgee: expression breadth ubiquitous, 218 present calls, max score 84.19.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 2.4207 / max 108.5483, expressed in 1069 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
180169	2.4207	1069

Top tissues by expression

240 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right uterine tube	UBERON:0001302	84.19	gold quality
bronchial epithelial cell	CL:0002328	83.42	gold quality
bronchus	UBERON:0002185	82.59	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	81.86	gold quality
body of pancreas	UBERON:0001150	81.26	gold quality
buccal mucosa cell	CL:0002336	80.86	gold quality
endothelial cell	CL:0000115	80.30	gold quality
pituitary gland	UBERON:0000007	80.29	gold quality
pancreas	UBERON:0001264	80.01	gold quality
adenohypophysis	UBERON:0002196	79.90	gold quality
islet of Langerhans	UBERON:0000006	79.80	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	79.49	gold quality
caput epididymis	UBERON:0004358	79.19	gold quality
lateral globus pallidus	UBERON:0002476	79.01	gold quality
corpus epididymis	UBERON:0004359	79.00	gold quality
thyroid gland	UBERON:0002046	78.95	gold quality
mucosa of paranasal sinus	UBERON:0005030	78.74	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	78.74	gold quality
left lobe of thyroid gland	UBERON:0001120	78.71	gold quality
left ovary	UBERON:0002119	78.65	gold quality
right lobe of thyroid gland	UBERON:0001119	78.49	gold quality
spinal cord	UBERON:0002240	78.28	gold quality
substantia nigra	UBERON:0002038	77.70	gold quality
right ovary	UBERON:0002118	77.57	gold quality
substantia nigra pars reticulata	UBERON:0001966	77.49	silver quality
cauda epididymis	UBERON:0004360	77.39	gold quality
muscle of leg	UBERON:0001383	77.35	gold quality
right adrenal gland	UBERON:0001233	77.25	gold quality
gastrocnemius	UBERON:0001388	77.15	gold quality
right adrenal gland cortex	UBERON:0035827	77.04	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	3.90

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 3)

• LOC284440 gene expression is decreased in follicular variant of papillary thyroid carcinoma. (PMID:21509594)
• LINC00663 was shown to be differentially expressed in various human tissues and cancer cell lines. (PMID:26743782)
• The Effect and Mechanism of LINC00663 on the Biological Behavior of Glioma. (PMID:33830405)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.