LINC00665

Summary

LINC00665 (long intergenic non-protein coding RNA 665, HGNC:44323) is a long non-coding RNA gene on chromosome 19q13.12.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:44323
Approved symbol	LINC00665
Name	long intergenic non-protein coding RNA 665
Location	19q13.12
Locus type	RNA, long non-coding
Status	Approved
Aliases	CIP2A-BP
Ensembl gene	ENSG00000232677
Ensembl biotype	lncRNA
Entrez	100506930
RNAcentral	URS000024466C — lncRNA, 1749 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 42 — 42 lncRNA

ENST00000412740, ENST00000427868, ENST00000438368, ENST00000449434, ENST00000585356, ENST00000590622, ENST00000590657, ENST00000591372, ENST00000651681, ENST00000656137, ENST00000658042, ENST00000658126, ENST00000658301, ENST00000658991, ENST00000659786, ENST00000661195, ENST00000662398, ENST00000665982, ENST00000666182, ENST00000666458, ENST00000667789, ENST00000667829, ENST00000668768, ENST00000668927, ENST00000674604, ENST00000675074, ENST00000675167, ENST00000675324, ENST00000675914, ENST00000676298, ENST00000676422, ENST00000689532, ENST00000691592, ENST00000702802, ENST00000702867, ENST00000784952, ENST00000784953, ENST00000784954, ENST00000784955, ENST00000784956, ENST00000784957, ENST00000784958

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000412740 — 7 exons

Exon	Start	End
ENSE00001606046	36315957	36316070
ENSE00002437037	36321300	36321357
ENSE00002438745	36322130	36322225
ENSE00002526014	36321993	36322030
ENSE00002797587	36330253	36330492
ENSE00003876806	36315005	36315528
ENSE00003882974	36331447	36331734

Expression profiles

Bgee: expression breadth ubiquitous, 163 present calls, max score 93.82.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 18.9281 / max 241.0985, expressed in 1495 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
180668	13.7584	1470
180667	5.1697	655

Top tissues by expression

245 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adenohypophysis	UBERON:0002196	93.82	gold quality
right uterine tube	UBERON:0001302	92.06	gold quality
right hemisphere of cerebellum	UBERON:0014890	91.88	gold quality
cerebellar hemisphere	UBERON:0002245	91.44	gold quality
cerebellar cortex	UBERON:0002129	91.25	gold quality
cortical plate	UBERON:0005343	91.07	gold quality
left lobe of thyroid gland	UBERON:0001120	90.75	gold quality
right lobe of thyroid gland	UBERON:0001119	90.57	gold quality
pituitary gland	UBERON:0000007	90.05	gold quality
ganglionic eminence	UBERON:0004023	89.80	gold quality
anterior cingulate cortex	UBERON:0009835	88.95	gold quality
sural nerve	UBERON:0015488	88.88	gold quality
ventricular zone	UBERON:0003053	88.86	gold quality
thyroid gland	UBERON:0002046	88.85	gold quality
right frontal lobe	UBERON:0002810	88.76	gold quality
Brodmann (1909) area 9	UBERON:0013540	88.62	gold quality
left ovary	UBERON:0002119	88.09	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	87.92	gold quality
cerebellum	UBERON:0002037	87.79	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	87.75	gold quality
islet of Langerhans	UBERON:0000006	87.54	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	86.98	gold quality
metanephros cortex	UBERON:0010533	86.69	gold quality
hypothalamus	UBERON:0001898	86.63	gold quality
nucleus accumbens	UBERON:0001882	86.53	gold quality
right ovary	UBERON:0002118	86.33	gold quality
caudate nucleus	UBERON:0001873	85.91	gold quality
putamen	UBERON:0001874	85.78	gold quality
lower esophagus mucosa	UBERON:0035834	85.71	gold quality
amygdala	UBERON:0001876	85.51	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	5.33

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 27)

• LINC00665 may be involved in the regulation of cell cycle pathways in hepatocellular carcinoma through ten identified hub genes. (PMID:29728556)
• Transcription factor SP1 induced the transcription of linc00665 in LUAD cells, which exerted its oncogenic role by functioning as competing endogenous RNA (ceRNA) for miR-98 and subsequently activating downstream AKR1B10-ERK signaling pathway. (PMID:30692511)
• LINC00665 induces gastric cancer progression through activating Wnt signaling pathway. (PMID:31736127)
• LINC00665 promotes breast cancer progression through regulation of the miR-379-5p/LIN28B axis. (PMID:31907362)
• Inflammation-Induced Long Intergenic Noncoding RNA (LINC00665) Increases Malignancy Through Activating the Double-Stranded RNA-Activated Protein Kinase/Nuclear Factor Kappa B Pathway in Hepatocellular Carcinoma. (PMID:32083756)
• Long non-coding RNA LINC00665 promotes metastasis of breast cancer cells by triggering EMT. (PMID:32271427)
• Downregulation of LINC00665 confers decreased cell proliferation and invasion via the miR-138-5p/E2F3 signaling pathway in NSCLC. (PMID:32403047)
• Long non-coding RNA linc00665 interacts with YB-1 and promotes angiogenesis in lung adenocarcinoma. (PMID:32423800)
• LINC00665 facilitates the progression of osteosarcoma via sponging miR-3619-5p. (PMID:33090388)
• LINC00665 promotes the progression of acute myeloid leukemia by regulating the miR-4458/DOCK1 pathway. (PMID:33658535)
• LINC00665 activates Wnt/beta-catenin signaling pathway to facilitate tumor progression of colorectal cancer via upregulating CTNNB1. (PMID:33865827)
• LINC00665 promotes HeLa cell proliferation, migration, invasion and epithelial-mesenchymal transition by activating the WNT-CTNNB1/betacatenin signaling pathway. (PMID:33903885)
• LINC00665 promotes the viability, migration and invasion of T cell acute lymphoblastic leukemia cells by targeting miR-101 via modulating PI3K/Akt pathway. (PMID:34171521)
• Downregulation of LINC00665 suppresses the progression of lung adenocarcinoma via regulating miR-181c-5p/ZIC2 axis. (PMID:34232917)
• LINC00665 Facilitates the Malignant Processes of Osteosarcoma by Increasing the RAP1B Expression via Sponging miR-708 and miR-142-5p. (PMID:34306997)
• LINC00665 interacts with BACH1 to activate Wnt1 and mediates the M2 polarization of tumor-associated macrophages in GC. (PMID:35395473)
• LncRNA LINC00665 Promotes Ovarian Cancer Cell Proliferation and Inhibits Apoptosis via Targeting miR-181a-5p/FHDC. (PMID:35524876)
• LINC00665: An Emerging Biomarker for Cancer Diagnostics and Therapeutics. (PMID:35563845)
• MicroRNA-122-3p plays as the target of long non-coding RNA LINC00665 in repressing the progress of arthritis. (PMID:35635065)
• Hepatitis B Virus-Encoded HBsAg Contributes to Hepatocarcinogenesis by Inducing the Oncogenic Long Noncoding RNA LINC00665 through the NF-kappaB Pathway. (PMID:35993712)
• LINC00665 affects the malignant biological behavior of ovarian cancer via the miR-148b-3p/KLF5. (PMID:36016468)
• Prognostic and clinicopathological values of LINC00665 in cancers: a systematic review and China population-based meta-analysis. (PMID:36219365)
• A Feedback Loop of LINC00665 and the Wnt Signaling Pathway Expedites Osteosarcoma Cell Proliferation, Invasion, and Epithelial-Mesenchymal Transition. (PMID:36387061)
• A short peptide LINC00665_18aa encoded by lncRNA LINC00665 suppresses the proliferation and migration of osteosarcoma cells through the regulation of the CREB1/RPS6KA3 interaction. (PMID:37285335)
• LINC00665 activating Wnt3a/beta-catenin signaling by bond with YBX1 promotes gastric cancer proliferation and metastasis. (PMID:37563362)
• Overexpression of lncRNA LINC00665 inhibits the proliferation and chondroblast differentiation of bone marrow mesenchymal stem cells by targeting miR-214-3p. (PMID:38167456)
• STAU1-mediated CNBP mRNA degradation by LINC00665 alters stem cell characteristics in ovarian cancer. (PMID:39080743)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.