LINC00667

Summary

LINC00667 (long intergenic non-protein coding RNA 667, HGNC:27906) is a long non-coding RNA gene on chromosome 18p11.31.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:27906
Approved symbol	LINC00667
Name	long intergenic non-protein coding RNA 667
Location	18p11.31
Locus type	RNA, long non-coding
Status	Approved
Aliases	lncOCMRL1
Ensembl gene	ENSG00000263753
Ensembl biotype	lncRNA
Entrez	339290
RNAcentral	URS00003F999A — lncRNA, 3979 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 54 — 54 lncRNA

ENST00000577439, ENST00000580082, ENST00000580684, ENST00000581471, ENST00000582008, ENST00000582363, ENST00000653507, ENST00000653571, ENST00000654021, ENST00000654155, ENST00000655685, ENST00000656810, ENST00000657129, ENST00000657250, ENST00000657955, ENST00000658226, ENST00000658607, ENST00000658946, ENST00000660030, ENST00000660561, ENST00000661357, ENST00000661829, ENST00000662359, ENST00000662415, ENST00000662652, ENST00000662932, ENST00000663393, ENST00000664934, ENST00000665272, ENST00000665442, ENST00000665541, ENST00000666552, ENST00000666950, ENST00000668495, ENST00000668807, ENST00000669192, ENST00000669574, ENST00000670993, ENST00000671289, ENST00000671312, ENST00000691055, ENST00000700921, ENST00000700949, ENST00000813556, ENST00000813557, ENST00000813558, ENST00000813559, ENST00000813560, ENST00000813561, ENST00000813562, ENST00000813563, ENST00000813564, ENST00000813565, ENST00000813566

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000577439 — 5 exons

Exon	Start	End
ENSE00002695154	5240648	5241255
ENSE00002705392	5241699	5241889
ENSE00003831893	5238780	5239049
ENSE00003840804	5240187	5240277
ENSE00004213780	5243594	5246508

Expression profiles

Bgee: expression breadth ubiquitous, 276 present calls, max score 90.23.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 10.9853 / max 108.5483, expressed in 1747 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
169243	10.6766	1744
169244	0.3087	165

Top tissues by expression

293 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
cortical plate	UBERON:0005343	90.23	gold quality
right atrium auricular region	UBERON:0006631	89.09	gold quality
hindlimb stylopod muscle	UBERON:0004252	88.97	gold quality
gastrocnemius	UBERON:0001388	88.88	gold quality
ganglionic eminence	UBERON:0004023	88.86	gold quality
muscle of leg	UBERON:0001383	88.85	gold quality
caput epididymis	UBERON:0004358	88.77	gold quality
jejunal mucosa	UBERON:0000399	88.47	gold quality
cardiac atrium	UBERON:0002081	88.46	gold quality
lower lobe of lung	UBERON:0008949	88.11	gold quality
heart left ventricle	UBERON:0002084	88.09	gold quality
cerebellar hemisphere	UBERON:0002245	88.04	gold quality
cardiac ventricle	UBERON:0002082	88.03	gold quality
cerebellar cortex	UBERON:0002129	87.96	gold quality
cerebellum	UBERON:0002037	87.90	gold quality
heart	UBERON:0000948	87.84	gold quality
right hemisphere of cerebellum	UBERON:0014890	87.83	gold quality
skeletal muscle tissue of biceps brachii	UBERON:0004502	87.70	gold quality
biceps brachii	UBERON:0001507	87.46	gold quality
Brodmann (1909) area 46	UBERON:0006483	87.42	gold quality
cauda epididymis	UBERON:0004360	87.26	gold quality
left ovary	UBERON:0002119	87.22	gold quality
muscle organ	UBERON:0001630	87.15	gold quality
lower esophagus muscularis layer	UBERON:0035833	87.10	gold quality
left coronary artery	UBERON:0001626	87.09	gold quality
inferior vagus X ganglion	UBERON:0005363	87.09	gold quality
lower esophagus	UBERON:0013473	87.05	gold quality
left uterine tube	UBERON:0001303	87.03	gold quality
right coronary artery	UBERON:0001625	87.03	gold quality
superficial temporal artery	UBERON:0001614	86.94	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	8.01

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 8)

• The key findings of this study demonstrated that decreased lncRNA LINC00667 could promote renal tubular epithelial cell proliferation and ameliorate renal fibrosis in chronic renal failure via the miR-19b-3p/LINC00667/connective tissue growth factor signaling pathway. (PMID:30555030)
• LINC00667 promotes Wilms’ tumor metastasis and stemness by sponging miR-200b/c/429 family to regulate IKK-beta. (PMID:32129525)
• LINC00667 promotes the proliferation, migration, and pathological angiogenesis in non-small cell lung cancer through stabilizing VEGFA by EIF4A3. (PMID:32281700)
• Down-regulation of LINC00667 hinders renal tubular epithelial cell apoptosis and fibrosis through miR-34c. (PMID:32705492)
• LINC00667 Promotes Progression of Esophageal Cancer Cells by Regulating miR-200b-3p/SLC2A3 Axis. (PMID:34313922)
• Docetaxel-resistant triple-negative breast cancer cell-derived exosomal lncRNA LINC00667 reduces the chemosensitivity of breast cancer cells to docetaxel via targeting miR-200b-3p/Bcl-2 axis. (PMID:36281649)
• N6-methyladenine- induced LINC00667 promoted breast cancer progression through m6A/KIAA1429 positive feedback loop. (PMID:36700472)
• LncRNA LINC00667 gets involved in clear cell renal cell carcinoma development and chemoresistance by regulating the miR-143-3p/ZEB1 axis. (PMID:37827696)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.