LINC00668

Summary

LINC00668 (long intergenic non-protein coding RNA 668, HGNC:44328) is a long non-coding RNA gene on chromosome 18p11.31.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:44328
Approved symbol	LINC00668
Name	long intergenic non-protein coding RNA 668
Location	18p11.31
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000265933
Ensembl biotype	lncRNA
Entrez	400643
RNAcentral	URS000075E986 — lncRNA, 1751 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 52 — 52 lncRNA

ENST00000578278, ENST00000578497, ENST00000579012, ENST00000580197, ENST00000581571, ENST00000581725, ENST00000583316, ENST00000583840, ENST00000773079, ENST00000773080, ENST00000773081, ENST00000773082, ENST00000773083, ENST00000773084, ENST00000773085, ENST00000773086, ENST00000773087, ENST00000773088, ENST00000773089, ENST00000773090, ENST00000773091, ENST00000773092, ENST00000773093, ENST00000773094, ENST00000773095, ENST00000773096, ENST00000773097, ENST00000773098, ENST00000773099, ENST00000773100, ENST00000773101, ENST00000773102, ENST00000773103, ENST00000773104, ENST00000773105, ENST00000773106, ENST00000773107, ENST00000773108, ENST00000773109, ENST00000773110, ENST00000773111, ENST00000773112, ENST00000773113, ENST00000773114, ENST00000773115, ENST00000773116, ENST00000773117, ENST00000773118, ENST00000773119, ENST00000773120, ENST00000773121, ENST00000773122

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000578278 — 6 exons

Exon	Start	End
ENSE00002685049	6928120	6928219
ENSE00002711689	6926440	6926558
ENSE00002724176	6925477	6925718
ENSE00004137748	6929915	6929994
ENSE00004137779	6926657	6927584
ENSE00004137780	6928851	6928965

Expression profiles

Bgee: expression breadth ubiquitous, 135 present calls, max score 96.51.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.1708 / max 93.5345, expressed in 48 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
171142	0.1408	36
171143	0.0243	16
171141	0.0057	1

Top tissues by expression

234 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
mucosa of transverse colon	UBERON:0004991	96.51	gold quality
left testis	UBERON:0004533	93.96	gold quality
right testis	UBERON:0004534	93.89	gold quality
testis	UBERON:0000473	89.55	gold quality
rectum	UBERON:0001052	86.65	gold quality
transverse colon	UBERON:0001157	83.81	gold quality
colonic epithelium	UBERON:0000397	82.01	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	80.35	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	75.31	gold quality
vermiform appendix	UBERON:0001154	75.04	gold quality
ileal mucosa	UBERON:0000331	74.18	silver quality
kidney epithelium	UBERON:0004819	72.09	gold quality
epithelial cell of pancreas	CL:0000083	71.09	gold quality
upper arm skin	UBERON:0004263	70.93	gold quality
tibialis anterior	UBERON:0001385	70.75	silver quality
colon	UBERON:0001155	70.19	gold quality
large intestine	UBERON:0000059	69.80	gold quality
small intestine Peyer’s patch	UBERON:0003454	69.73	gold quality
intestine	UBERON:0000160	69.29	gold quality
small intestine	UBERON:0002108	68.70	gold quality
caecum	UBERON:0001153	68.49	gold quality
smooth muscle tissue	UBERON:0001135	67.86	gold quality
body of pancreas	UBERON:0001150	64.88	gold quality
skeletal muscle tissue of rectus abdominis	UBERON:0004511	64.55	gold quality
pancreas	UBERON:0001264	61.83	gold quality
prostate gland	UBERON:0002367	61.22	gold quality
lower lobe of lung	UBERON:0008949	60.86	silver quality
colonic mucosa	UBERON:0000317	60.33	gold quality
monocyte	CL:0000576	59.78	gold quality
adrenal tissue	UBERON:0018303	58.84	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	5.90

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 9)

• High LINC00668 expression is associated with gastric cancer. (PMID:27036039)
• High LINC00668 expression is associated with laryngeal squamous cell carcinoma. (PMID:30415008)
• STAT3-induced LINC00668 contributed to non-small cell lung cancer progression through upregulating KLF7 expression by sponging miR-193a. (PMID:31150989)
• lncRNA LINC00668 acted as an oncogenic role in CRC cells by sponging miR-188-5p and upregulating USP47 (PMID:31233752)
• Study identified that lncRNA LINC00668 is differentially expressed and upregulated in hepatocellular carcinoma (HCC) tissue. It functions as an oncogene and its high expression leads to poor prognosis for HCC. (PMID:31432149)
• LncRNA LINC00668 promotes cell proliferation, migration, invasion ability and EMT process in hepatocellular carcinoma by targeting miR-532-5p/YY1 axis. (PMID:32249890)
• LINC00668 Modulates SOCS5 Expression Through Competitively Sponging miR-518c-3p to Facilitate Glioma Cell Proliferation. (PMID:32279214)
• [LINC00668 is Highly Expressed in Lung Squamous Cell Carcinoma and Promotes Tumor Cell Migration and Invasion]. (PMID:35477186)
• LINC00668 promoted non-small lung cancer progression by miR-518c-3p/TRIP4 axis. (PMID:37718780)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.